Agier M-S, Chollet N, Bediou E, Boyer Gervoise M, Jonville-Bera A-P
Service de pharmacosurveillance, centre régional de pharmacovigilance, centre Val-de-Loire, CHRU de Tours, 37044 Tours cedex, France; SPHERE U1246, Inserm, université de Nantes, université de Tours, 37000 Tours, France.
Service de la protection maternelle et infantile, Conseil départemental du Loir et Cher, 41000 Blois, France.
Arch Pediatr. 2019 Sep;26(6):358-360. doi: 10.1016/j.arcped.2019.06.005. Epub 2019 Jul 19.
We report the case of a 4-month-old baby boy who presented hypothermia (rectal temperature 36°C) after acetaminophen intake for post-vaccination fever. A recurrence of the hypothermia was observed after acetaminophen rechallenge for fever. We reviewed 14 other pediatric cases of hypothermia secondary to therapeutic doses of acetaminophen. Hypothermia after a therapeutic dose is a very rare side effect of acetaminophen. Several hypotheses have been made but the exact mechanism remains unknown.
我们报告了一例4个月大男婴的病例，该患儿在接种疫苗后因发热服用对乙酰氨基酚后出现体温过低（直肠温度36°C）。在因发热再次服用对乙酰氨基酚后，再次观察到体温过低。我们回顾了另外14例因治疗剂量对乙酰氨基酚导致体温过低的儿科病例。治疗剂量后出现体温过低是对乙酰氨基酚非常罕见的副作用。已经提出了几种假设，但确切机制仍不清楚。
