Börsch G, Schmidt G, Wegener M, Sandmann M, Adamek R, Leverkus F, Reitemeyer E
Department of Medicine, St Josef-Hospital, Bochum, FRG.
Eur J Clin Invest. 1988 Apr;18(2):133-8. doi: 10.1111/j.1365-2362.1988.tb02403.x.
The association of Campylobacter pylori (C.p.) colonization of the upper gastrointestinal tract with five predefined anamnestic variables, seven symptoms of dyspepsia, and various blindly evaluated histological criteria, was prospectively investigated in a consecutive series of 149 patients submitted to upper gastrointestinal tract endoscopy. Colonization was determined by biopsy urease tests and histological searches. Significant differences (P less than 0.05) between C.p.-positive and C.p.-negative patients were found for smoker status and the frequency of therapy with ulcer-healing drugs (positive association with C.p.) and antibiotics (negative association), but not for any other of the anamnestic data or symptoms. These data were further submitted to stepwise multiple logistic regression analyses. Concerning histological findings, C.p. colonization was significantly associated with the degree of antrum and body gastritis (P less than 0.01), and also with lymphocellular infiltration in antrum and body biopsies and neutrophil cellular grading in gastric antra. We conclude that C.p. colonization of the upper gastrointestinal tract is associated with gastritic change of the antrum and, albeit to a lesser extent, of the body mucosa. However, a specific pattern of symptoms to predict C.p. colonization could not be established.
对连续149例接受上消化道内镜检查的患者进行前瞻性研究，以探讨上消化道幽门螺杆菌（C.p.）定植与五个预先定义的既往史变量、七种消化不良症状以及各种盲目评估的组织学标准之间的关联。通过活检尿素酶试验和组织学检查确定定植情况。在吸烟状况以及溃疡愈合药物治疗频率（与C.p.呈正相关）和抗生素治疗频率（与C.p.呈负相关）方面，C.p.阳性和C.p.阴性患者之间存在显著差异（P<0.05），但在任何其他既往史数据或症状方面均无差异。这些数据进一步进行逐步多元逻辑回归分析。关于组织学发现，C.p.定植与胃窦和胃体胃炎程度（P<0.01）显著相关，也与胃窦和胃体活检中的淋巴细胞浸润以及胃窦中性粒细胞分级相关。我们得出结论，上消化道C.p.定植与胃窦胃炎改变相关，尽管程度较轻，但也与胃体黏膜改变相关。然而，无法建立预测C.p.定植的特定症状模式。
