Holtmann G, Goebell H, Holtmann M, Talley N J
Division of Gastroenterology, University of Essen, Germany.
Dig Dis Sci. 1994 May;39(5):1090-8. doi: 10.1007/BF02087563.
Whether Helicobacter pylori is causally linked to dyspepsia remains controversial. The aims of this study were to assess in healthy blood donors the prevalence of dyspepsia and dyspepsia subgroups, determine if H. pylori is associated with different categories of dyspeptic symptoms, and evaluate the association between dyspepsia and nicotine, alcohol, and analgesic use. Consecutive blood donors (N = 180) who had no clinical evidence of organic disease were included. Abdominal symptoms were measured by means of a standardized questionnaire that has been previously validated. Subjects with dyspepsia (defined as pain localized to the upper abdomen) were further subdivided into those with ulcer-like, dysmotility-like, reflux-like, or nonspecific dyspepsia. A total of 65 subjects reported abdominal pain or discomfort during the prior 12 months [36.1%, 95% confidence interval (CI) 29.1-43.1]; 44 subjects (24.4%, 95% CI 18.2-30.7) had dyspepsia. Dysmotility-like, reflux-like, and ulcer-like symptoms were reported by 19.4% (95% CI 13.7-25.2), 17.2% (95% CI 11.7-22.7), and 16.7% (95% CI 11.2-22.1) of subjects with dyspepsia, respectively. Fifty-seven subjects (31.7%, 95% CI 24.9-38.5) were H. pylori positive; 26% of subjects with H. pylori and 24% without H. pylori had dyspepsia (P > 0.50). The seroprevalence of H. pylori was also similar among the different categories of dyspepsia. We conclude that infection with H. pylori is not associated with abdominal complaints in otherwise healthy subjects.
幽门螺杆菌与消化不良之间是否存在因果关系仍存在争议。本研究的目的是评估健康献血者中消化不良及其亚组的患病率，确定幽门螺杆菌是否与不同类型的消化不良症状相关，并评估消化不良与尼古丁、酒精和镇痛药使用之间的关联。纳入了180名无器质性疾病临床证据的连续献血者。通过先前已验证的标准化问卷来测量腹部症状。消化不良患者（定义为上腹部局限性疼痛）进一步细分为溃疡样、动力障碍样、反流样或非特异性消化不良患者。共有65名受试者报告在过去12个月内有腹痛或不适[36.1%，95%置信区间（CI）29.1 - 43.1]；44名受试者（24.4%，95% CI 18.2 - 30.7）有消化不良。有消化不良的受试者中，分别有19.4%（95% CI 13.7 - 25.2）、17.2%（95% CI 11.7 - 22.7）和16.7%（95% CI 11.2 - 22.1）报告有动力障碍样、反流样和溃疡样症状。57名受试者（31.7%，95% CI 24.9 - 38.5）幽门螺杆菌呈阳性；幽门螺杆菌阳性的受试者中有26%以及幽门螺杆菌阴性的受试者中有24%有消化不良（P>0.50）。幽门螺杆菌的血清阳性率在不同类型的消化不良中也相似。我们得出结论，在其他方面健康的受试者中，幽门螺杆菌感染与腹部不适无关。
