Department of Breast Surgery, Peking Union Medical College Hospital, Peking Union Medical College, Chinese Academy of Medical Sciences, Beijing, 100730, P.R. China.
Department of Radiology, Peking Union Medical College Hospital, Peking Union Medical College, Chinese Academy of Medical Sciences, Beijing, 100730, P.R. China.
Sci Rep. 2019 Jul 22;9(1):10544. doi: 10.1038/s41598-019-47118-3.
This study aimed to determine whether there is an association between mammographic casting-type calcification and other prognostic factors for invasive breast cancer. We also assessed whether casting-type calcification could be an independent prognostic factor. Invasive breast cancer patient information from January 2010 and January 2013 was retrospectively reviewed. The associations between mammographic casting-type calcification and other clinicopathological factors, including tumor size, node status, grade, progesterone receptor (PR) status, estrogen receptor (ER) status, and human epidermal growth factor receptor 2 (HER2) status, were analyzed. The Kaplan-Meier method and a Cox proportional hazards model were used for survival analyses of disease-free survival (DFS) and overall survival (OS). A total of 1155 invasive breast cancer patients who underwent definitive surgery were included, and 136 cases (11.8%) had casting-type calcification on mammography. In multivariate logistic regression, casting-type calcification was significantly associated with axillary node metastasis, ER-negativity, and HER2 overexpression. Casting-type calcification significantly decreased OS and DFS after a median follow-up of 60 months. This result remained after adjusting other prognostic factors in the multivariate analysis. Casting-type calcification is significantly linked to axillary node metastasis, ER-negativity and HER2 overexpression. Casting-type calcification is therefore an independent prognostic factor for breast cancer patients.
本研究旨在确定乳腺 X 线摄影中的铸型钙化与浸润性乳腺癌其他预后因素之间是否存在关联。我们还评估了铸型钙化是否可以作为一个独立的预后因素。回顾性分析了 2010 年 1 月至 2013 年 1 月期间的浸润性乳腺癌患者信息。分析了乳腺 X 线摄影中的铸型钙化与其他临床病理因素（包括肿瘤大小、淋巴结状态、分级、孕激素受体（PR）状态、雌激素受体（ER）状态和人表皮生长因子受体 2（HER2）状态）之间的关联。采用 Kaplan-Meier 方法和 Cox 比例风险模型对无病生存（DFS）和总生存（OS）进行生存分析。共纳入 1155 例接受确定性手术的浸润性乳腺癌患者，其中 136 例（11.8%）乳腺 X 线摄影显示为铸型钙化。多变量逻辑回归分析显示，铸型钙化与腋窝淋巴结转移、ER 阴性和 HER2 过表达显著相关。在中位随访 60 个月后，铸型钙化显著降低了 OS 和 DFS。这一结果在多变量分析中调整了其他预后因素后仍然存在。铸型钙化与腋窝淋巴结转移、ER 阴性和 HER2 过表达显著相关。因此，铸型钙化是乳腺癌患者的一个独立预后因素。
