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Nat Mater. 2019 Aug;18(8):883-891. doi: 10.1038/s41563-019-0307-6. Epub 2019 Mar 18.
2
Effects of Matrix Stiffness on the Morphology, Adhesion, Proliferation and Osteogenic Differentiation of Mesenchymal Stem Cells.基质硬度对间充质干细胞形态、黏附、增殖和成骨分化的影响。
Int J Med Sci. 2018 Jan 15;15(3):257-268. doi: 10.7150/ijms.21620. eCollection 2018.
3
Encoding Stem-Cell-Secreted Extracellular Matrix Protein Capture in Two and Three Dimensions Using Protein Binding Peptides.使用蛋白结合肽在二维和三维空间中编码干细胞分泌的细胞外基质蛋白捕获。
Biomacromolecules. 2018 Mar 12;19(3):721-730. doi: 10.1021/acs.biomac.7b01482. Epub 2018 Feb 22.
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Identification of Three Early Phases of Cell-Fate Determination during Osteogenic and Adipogenic Differentiation by Transcription Factor Dynamics.通过转录因子动态鉴定成骨和成脂分化过程中细胞命运决定的三个早期阶段。
Stem Cell Reports. 2017 Apr 11;8(4):947-960. doi: 10.1016/j.stemcr.2017.02.018. Epub 2017 Mar 23.
5
Surface topography enhances differentiation of mesenchymal stem cells towards osteogenic and adipogenic lineages.表面形貌增强间充质干细胞向成骨细胞和脂肪细胞谱系的分化。
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6
Role of YAP/TAZ in mechanotransduction.YAP/TAZ 在机械转导中的作用。
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7
TAZ, a transcriptional modulator of mesenchymal stem cell differentiation.TAZ，一种间充质干细胞分化的转录调节因子。
Science. 2005 Aug 12;309(5737):1074-8. doi: 10.1126/science.1110955.

通过矩阵掌握自己的命运。

Mastering their own fates through the matrix.

机构信息

Department of Chemical and Biomolecular Engineering, University of California, Berkeley, CA, USA.

Department of Bioengineering, University of California, Berkeley, CA, USA.

出版信息

Nat Mater. 2019 Aug;18(8):779-780. doi: 10.1038/s41563-019-0429-x.

DOI:10.1038/s41563-019-0429-x
PMID:31332317
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC6894983/
Abstract

With their ability to give rise to many different cell types, stem cells have long been a target of scientists who seek to achieve control over their differentiation. New evidence suggests that stem cells influence their own fates through protein deposition and physical remodelling of their microenvironment.

摘要

干细胞具有分化为多种不同细胞类型的能力，长期以来一直是科学家们的目标，他们试图实现对干细胞分化的控制。新的证据表明，干细胞通过蛋白质沉积和微环境的物理重塑来影响自身命运。