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PARP inhibition - opportunities in pancreatic cancer.

作者信息

Pant Shubham, Maitra Anirban, Yap Timothy A

机构信息

Department of Investigational Cancer Therapeutics (Phase I Program), The University of Texas MD Anderson Cancer Center, Houston, TX, USA.

Department of Gastrointestinal Medical Oncology, The University of Texas MD Anderson Cancer Center, Houston, TX, USA.

出版信息

Nat Rev Clin Oncol. 2019 Oct;16(10):595-596. doi: 10.1038/s41571-019-0257-6.

DOI:10.1038/s41571-019-0257-6
PMID:31332344
Abstract
摘要

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PARP inhibition - opportunities in pancreatic cancer.聚（ADP-核糖）聚合酶抑制——胰腺癌治疗中的机遇
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Histone deacetylase inhibitor, suberoylanilide hydroxamic acid (SAHA), enhances anti-tumor effects of the poly (ADP-ribose) polymerase (PARP) inhibitor olaparib in triple-negative breast cancer cells.组蛋白去乙酰化酶抑制剂，辛二酰苯胺异羟肟酸（SAHA），增强了聚（ADP - 核糖）聚合酶（PARP）抑制剂奥拉帕尼在三阴性乳腺癌细胞中的抗肿瘤作用。
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