Department of Breast Surgery, Harbin Medical University Cancer Hospital, Harbin, China.
Department of Epidemiology, School of Public Health, Harbin Medical University, Harbin, China.
J Cell Physiol. 2020 Feb;235(2):1795-1807. doi: 10.1002/jcp.29098. Epub 2019 Jul 22.
The function of Fer-1 like family member 4 (FER1L4) in human pan-cancer is unknown. Expression of FER1L4 in tumor tissues and nontumor tissues, upstream regulation of FER1L4, and the relationship between its expression with prognosis and chemoresistance were examined by The Cancer Genome Atlas and Gene Expression Omnibus databases. Next, these results were validated in breast tumor and paired nontumor tissues in our cohort. FER1L4 expression is higher in tumor tissues compared with the adjacent nontumor tissues. High FER1L4 expression is associated with worse disease outcomes. Hypomethylation and H3K4me3 accumulation in FER1L4 promoter locus activate its transcriptional expression. Moreover, FER1L4 may trigger chemoresistance in human cancer. Gene Ontology enrichment analysis revealed that FER1L4 may be involved in processes associated with tumorigenesis. These results indicated that FER1L4 may act as an oncogenic driver and it may be a potential therapy target in human cancer.
FER1 样家族成员 4（FER1L4）在人类泛癌中的功能未知。通过癌症基因组图谱和基因表达综合数据库，检测了 FER1L4 在肿瘤组织和非肿瘤组织中的表达、FER1L4 的上游调控以及其表达与预后和化疗耐药性的关系。然后，在我们的队列中验证了这些结果在乳腺癌肿瘤和配对非肿瘤组织中的应用。与相邻非肿瘤组织相比，肿瘤组织中 FER1L4 的表达更高。高 FER1L4 表达与不良的疾病结局相关。FER1L4 启动子区域的低甲基化和 H3K4me3 积累激活其转录表达。此外，FER1L4 可能引发人类癌症的化疗耐药性。基因本体论富集分析表明，FER1L4 可能参与与肿瘤发生相关的过程。这些结果表明，FER1L4 可能作为致癌驱动因子发挥作用，它可能是人类癌症的潜在治疗靶点。
