Pérez-López Alberto, Valadés David, de Cos Blanco Ana I, García-Honduvilla Natalio, Vázquez Martínez Clotilde
Department of Medicine and Medical Specialties, Faculty of Medicine and Health Sciences, University of Alcalá, Madrid, Spain -
Biomedical Research Networking Center on Bioengineering, Biomaterials and Nanomedicine (CIBER-BBN), Madrid, Spain -
J Sports Med Phys Fitness. 2019 Jul;59(7):1229-1237. doi: 10.23736/S0022-4707.18.09030-8.
Adiponectin is an adipokine with oxidative, anti-inflammatory and antiatherogenic effects in several peripheral tissues; however, circulating adiponectin expression is reduced in cardio-metabolic diseases. The aim of this study was to ascertain whether regular physical activity mediates circulating adiponectin concentrations at baseline in an obese population.
Two hundred and twenty-one obese participants were divided into 6 groups according to gender, physical activity (PA), and type 2 diabetes mellitus (T2DM) diagnosis: A and B) obese PA females (N.=28) and males (N.=33); C and D) obese non-PA females (N.=40) and males (N.=40); E and F) obese non-PA females (N.=40) and males (N.=40) with T2DM. Serum adiponectin, IL-15 and IL-15Rα, blood glucose/lipid profile, and body composition were measured.
Circulating adiponectin increased in PA participants compared to non-PA (ANOVA, P=0.001), finding higher concentrations in females compared to males (P<0.001), particularly in the PA group (P=0.005). Serum adiponectin was associated with age (R2=0.068), body mass (R2=-0.108), waist circumference (WC) (R2=-0.122), LDL (R2=-0.045), triglycerides (R2=-0.043), and serum IL-15Rα (R2=-0.243), as well as fat mass in females (R2=0.098), and WC in males (R2=0.112).
Circulating adiponectin increased in obese PA participants (≥180 min/week) compared to non-PA counterparts, indicating that physical activity may mediate baseline adiponectin levels irrespective of the fat mass regulatory effect. The inverse relationship found between serum adiponectin and IL-15Rα may support the regulative role of the IL-15/IL-15Rα complex on this adipokine at baseline.
脂联素是一种脂肪因子，在多个外周组织中具有氧化、抗炎和抗动脉粥样硬化作用；然而，在心脏代谢疾病中，循环脂联素表达降低。本研究的目的是确定规律的体育活动是否能调节肥胖人群基线时的循环脂联素浓度。
221名肥胖参与者根据性别、体育活动（PA）和2型糖尿病（T2DM）诊断分为6组：A组和B组）肥胖的PA女性（N = 28）和男性（N = 33）；C组和D组）肥胖的非PA女性（N = 40）和男性（N = 40）；E组和F组）肥胖的患有T2DM的非PA女性（N = 40）和男性（N = 40）。测量血清脂联素、白细胞介素-15（IL-15）和IL-15受体α（IL-15Rα）、血糖/血脂谱和身体成分。
与非PA参与者相比，PA参与者的循环脂联素增加（方差分析，P = 0.001），女性的浓度高于男性（P < 0.001），特别是在PA组（P = 0.005）。血清脂联素与年龄（R2 = 0.068）、体重（R2 = -0.108）、腰围（WC）（R2 = -0.122）、低密度脂蛋白（LDL）（R2 = -0.045）、甘油三酯（R2 = -0.043）和血清IL-15Rα（R2 = -0.243）相关，在女性中与脂肪量（R2 = 0.098）相关，在男性中与WC（R2 = 0.112）相关。
与非PA的肥胖参与者相比，肥胖的PA参与者（每周≥180分钟）的循环脂联素增加，这表明体育活动可能调节基线脂联素水平，而与脂肪量调节作用无关。血清脂联素与IL-15Rα之间的负相关关系可能支持IL-15/IL-15Rα复合物在基线时对这种脂肪因子的调节作用。
