The Institute for Drug Research, School of Pharmacy, Faculty of Medicine, The Hebrew University Jerusalem, Jerusalem, Israel.
Department of Pharmaceutical and Pharmacological Sciences, School of Medicine, University of Padova, Padova, Italy.
Curr Pharm Des. 2019;25(21):2338-2348. doi: 10.2174/1381612825666190716095826.
Ethosomes are nanovesicular carriers for dermal administration. Phospholipids, ethanol at relatively high concentrations (up to 50%) and water are their main components. Ethosomes are what we call "soft vesicles" with fluid bilayers due to the presence of ethanol. The composition and structure of the vesicles augment their ability to entrap molecules with various physicochemical properties and deliver them to the deep strata of skin. Since their first design, ethosomal systems have been extensively investigated for a wide range of applications. This review focuses on work carried out in vitro, in vivo in animal models and in humans in clinical studies, with ethosomal formulations containing natural active molecules for the treatment of skin disorders. Skin bacterial and fungal infections, skin inflammation, acne vulgaris, arthritis, and skin cancer are examples of disorders managed successfully by ethosomal systems. Furthermore, Ethosomes loaded with a number of naturally occurring compounds for cosmetic applications are also reported. The efficient treatments together with a good safety profile and lack of toxicity or irritation paved the way towards the development of new dermal therapies.
醇质体是用于经皮给药的纳米囊泡载体。其主要成分包括磷脂、乙醇（浓度相对较高，可达 50%）和水。由于乙醇的存在，醇质体是我们所说的“软囊泡”，具有流动性双层。囊泡的组成和结构提高了其捕获具有各种物理化学性质的分子并将其递送至皮肤深层的能力。自首次设计以来，醇质体系统已广泛应用于治疗皮肤疾病的天然活性分子的各种制剂的体外、动物模型体内和临床研究中。本综述重点介绍了用于治疗皮肤细菌和真菌感染、皮肤炎症、寻常痤疮、关节炎和皮肤癌等疾病的醇质体制剂的研究工作。此外，还报道了负载许多天然存在的化合物用于化妆品应用的醇质体。高效的治疗方法、良好的安全性概况以及缺乏毒性或刺激性为开发新的皮肤疗法铺平了道路。
