College of Pharmacy, Amman Arab University, Jordan.
J Cosmet Dermatol. 2024 Jan;23(1):17-26. doi: 10.1111/jocd.15895. Epub 2023 Jul 2.
In a world where hair loss, acne, and skin whitening are common concerns, ethosomes emerge as a captivating breakthrough in cosmetic drug delivery.
This review provides a comprehensive overview of the ethosomal system and assesses its potential as an effective nanocarrier for delivering active ingredients to the skin. The focus is on exploring their applications in various pathologies, particularly skin disorders such as acne, hair loss, and skin pigmentation.
Ethosomes are a novel type of vesicular nanocarrier composed of high concentrations of ethanol (20-45%) and phospholipids. Their unique structure and composition make them an ideal choice for transporting active ingredients through the skin, offering targeted and effective treatment. The inclusion of ethanol in ethosomes' composition gives them distinctive properties, including flexibility, deformability, and stability, facilitating deep penetration into the skin and enhancing medication deposition. Moreover, ethosomes improved theoverall drug-loading capacity, and specificity of target treatment CONCLUSION: Ethosomes represent a unique and suitable approach for delivering active cosmetic ingredients in the treatment of hair loss, acne, and skin whitening, presenting a versatile alternative to traditional dermal delivery systems. Despite the challenges associated with their complex preparation and sensitivity to temperature and humidity, the remarkable potential benefits of ethosomes cannot be ignored. Further research is crucial to unlock their full potential, understand their limitations, and refine their formulations and administration methods. Ethosomes hold the promise of transforming the way we address these cosmetic concerns, offering an exciting glimpse into the future of advanced skincare solutions.
在一个脱发、粉刺和皮肤美白普遍存在的世界里，醇质体作为一种引人注目的化妆品药物输送突破出现了。
本文综述了醇质体系统，并评估了其作为一种有效的纳米载体将活性成分递送至皮肤的潜力。重点探讨了它们在各种病理情况下的应用，特别是在皮肤疾病如痤疮、脱发和皮肤色素沉着方面的应用。
醇质体是一种新型的囊泡纳米载体，由高浓度乙醇（20-45%）和磷脂组成。它们独特的结构和组成使它们成为通过皮肤输送活性成分的理想选择，提供靶向和有效的治疗。醇质体组成中包含的乙醇赋予它们独特的性质，包括灵活性、变形性和稳定性，促进了深度渗透到皮肤中，并增强了药物沉积。此外，醇质体提高了整体药物载药量和靶向治疗的特异性。
醇质体代表了一种独特而合适的方法，可用于治疗脱发、粉刺和皮肤美白的活性美容成分的输送，为传统的皮肤给药系统提供了一种多功能的替代方案。尽管醇质体的复杂制备以及对温度和湿度的敏感性带来了挑战，但不容忽视它们显著的潜在益处。进一步的研究对于挖掘其全部潜力、了解其局限性以及改进其配方和给药方法至关重要。醇质体有望改变我们解决这些美容问题的方式，为先进的皮肤护理解决方案带来令人兴奋的未来前景。
