Institut Galien Paris-Sud, CNRS UMR 8612, Univ Paris-Sud, Universite Paris-Saclay, Faculte de Pharmacie, France.
Curr Pharm Des. 2019;25(21):2349-2363. doi: 10.2174/1381612825666190716110919.
Rheology, the study of the flow and deformation of matter, can be a daunting subject for scientists new to this field. However, its importance in characterization and optimization of formulations is indisputable. This review intends to provide basic and practical rheological notions in order to better understand the key concepts such as shear stress, shear rate, viscosity, elastic and viscous moduli and phase angle, and learn to distinguish between flow and oscillation experiments. We will explain the different rheological behaviors such as shear thinning, thixotropy or viscoelasticity. Throughout this review, these concepts will be illustrated with examples taken from pharmaceutical and cosmetic formulations. Rheology is a broad subject and this review does not intend to be comprehensive, but rather to be concise and pedagogical.
流变学，研究物质的流动和变形，对于这个领域的新手科学家来说可能是一个令人生畏的主题。然而，它在制剂的表征和优化中的重要性是不可争议的。本综述旨在提供基本和实用的流变学概念，以便更好地理解关键概念，如剪切应力、剪切速率、粘度、弹性和粘性模量以及相角，并学会区分流动和振荡实验。我们将解释不同的流变行为，如剪切稀化、触变性或粘弹性。在整个综述中，这些概念将通过来自药物和化妆品制剂的示例进行说明。流变学是一个广泛的主题，本综述并不打算面面俱到，而是简洁和具有教学性。
