腺苷及其受体在炎症、神经炎症、IBS、自身免疫性炎症性疾病、类风湿关节炎和银屑病中的作用和功能。

Role and Function of Adenosine and its Receptors in Inflammation, Neuroinflammation, IBS, Autoimmune Inflammatory Disorders, Rheumatoid Arthritis and Psoriasis.

机构信息

Medicinal Chemistry, Drug Design and Drug Metabolism, Department of Pharmaceutical Sciences, Faculty of Pharmacy, Al- Ahliyya Amman University, PO Box 263, Amman 19328, Jordan.

Department of Medical Laboratory Sciences, Faculty of Allied Medical Sciences, Al-Ahliyya Amman University, Amman 19328, Jordan.

出版信息

Curr Pharm Des. 2019;25(26):2875-2891. doi: 10.2174/1381612825666190716145206.

DOI:10.2174/1381612825666190716145206

PMID:31333103

Abstract

The physiological effects of endogenous adenosine on various organ systems are very complex and numerous which are elicited upon activation of any of the four G-protein-coupled receptors (GPCRs) denoted as A1, A2A, A2B and A3 adenosine receptors (ARs). Several fused heterocyclic and non-xanthine derivatives are reported as a possible target for these receptors due to physiological problems and lack of selectivity of xanthine derivatives. In the present review, we have discussed the development of various new chemical entities as a target for these receptors. In addition, compounds acting on adenosine receptors can be utilized in treating diseases like inflammation, neuroinflammation, autoimmune and related diseases.

摘要

内源性腺苷对各种器官系统的生理影响非常复杂和多样，这些影响是在激活任何四种 G 蛋白偶联受体（GPCR）之一时引发的，这四种 GPCR 分别表示为 A1、A2A、A2B 和 A3 腺苷受体（AR）。由于生理问题和黄嘌呤衍生物缺乏选择性，几种融合杂环和非黄嘌呤衍生物被报道为这些受体的可能靶标。在本综述中，我们讨论了将各种新的化学实体作为这些受体的靶标进行开发的情况。此外，作用于腺苷受体的化合物可用于治疗炎症、神经炎症、自身免疫和相关疾病等疾病。