Feoktistov I, Polosa R, Holgate S T, Biaggioni I
Division of Cardiology, Vanderbilt University, Nashville, TN 37232-2195, USA.
Trends Pharmacol Sci. 1998 Apr;19(4):148-53. doi: 10.1016/s0165-6147(98)01179-1.
Adenosine is an endogenous nucleoside that modulates many physiological processes. Its actions are mediated by interaction with specific cell membrane receptors. Four subtypes of adenosine receptor have been cloned: A1, A2A, A2B and A3. Significant advancement has been made in our understanding of the molecular pharmacology and physiological relevance of adenosine receptors but our knowledge of A2B receptors lags behind that of other receptor types. Only recently have potentially important functions been discovered for the A2B receptors, prompting a renewed interest in this receptor type. A2B receptors have been implicated in the regulation of vascular smooth muscle tone, cell growth, intestinal function and neurosecretion. In this review, Igor Feoktistov, Riccardo Polosa, Stephen Holgate and Italo Biaggioni focus on the role of A2B receptors in mast cell activation and the potential relevance of this action on asthma.
腺苷是一种调节多种生理过程的内源性核苷。其作用通过与特定细胞膜受体相互作用介导。已克隆出四种腺苷受体亚型：A1、A2A、A2B和A3。我们对腺苷受体的分子药理学和生理相关性的理解有了显著进展，但我们对A2B受体的了解落后于其他受体类型。直到最近才发现A2B受体具有潜在的重要功能，这引发了对该受体类型的新兴趣。A2B受体与血管平滑肌张力调节、细胞生长、肠道功能和神经分泌有关。在这篇综述中，伊戈尔·费奥克季斯托夫、里卡尔多·波洛萨、斯蒂芬·霍尔盖特和伊塔洛·比亚焦尼重点探讨了A2B受体在肥大细胞活化中的作用以及这一作用与哮喘的潜在相关性。
