Research Center for Biochemistry and Nutrition in Metabolic Diseases, Kashan University of Medical Sciences, Kashan, Iran.
Department of Cellular and Structural Biology, University of Texas Health Science Center, San Antonio, TX, United States.
Curr Pharm Des. 2019;25(19):2178-2191. doi: 10.2174/1381612825666190717110932.
The prevalence of neurodegenerative disorders characterized by the loss of neuronal function is rapidly increasing. The pathogenesis of the majority of these diseases is not entirely clear, but current evidence has shown the possibility that autophagy, apoptosis, inflammation and oxidative stress are involved. The present review summarizes the therapeutic effects of resveratrol on neurodegenerative disorders, based on the especially molecular biology of these diseases. The PubMed, Cochrane, Web of Science and Scopus databases were searched for studies published in English until March 30th, 2019 that contained data for the role of inflammation, oxidative stress, angiogenesis and apoptosis in the neurodegenerative disorders. There are also studies documenting the role of molecular processes in the progression of central nervous system diseases. Based on current evidence, resveratrol has potential properties that may reduce cell damage due to inflammation. This polyphenol affects cellular processes, including autophagy and the apoptosis cascade under stressful conditions. Current evidence supports the beneficial effects of resveratrol on the therapy of neurodegenerative disorders.
神经退行性疾病的患病率以神经元功能丧失为特征，正在迅速增加。这些疾病中的大多数的发病机制尚不完全清楚，但现有证据表明自噬、细胞凋亡、炎症和氧化应激可能参与其中。本综述基于这些疾病的分子生物学，总结了白藜芦醇对神经退行性疾病的治疗作用。检索了截至 2019 年 3 月 30 日发表的英文文献，包含炎症、氧化应激、血管生成和细胞凋亡在神经退行性疾病中的作用的数据，以及记录中枢神经系统疾病进展中分子过程作用的研究。基于现有证据，白藜芦醇具有减轻炎症引起的细胞损伤的潜在特性。这种多酚影响包括自噬和应激条件下细胞凋亡级联在内的细胞过程。现有证据支持白藜芦醇对神经退行性疾病治疗的有益作用。
