Department of Biology, Faculty of Sciences, University of Tehran, Iran.
Department of Basic Sciences, Neyshabur University of Medical Sciences, Neyshabur, 9318614139, Iran.
Curr Mol Med. 2024;24(7):867-875. doi: 10.2174/1566524023666230602162949.
Resveratrol (Res), a polyphenol found in red wine, has been shown to decelerate aging, the progressive loss of physiological integrity and cellular senescence, characterized by the inability to progress through the cell cycle. No successful clinical trials have yet to be completed in humans on dose limitations. Yet, the potent anti-aging and anti-senescence efficacy of Res has been documented in several in vivo animal models. In this review, we highlight the molecular mechanisms of Res efficacy in antiaging disorders, such as diabetes, neurodegenerative disorders, eye diseases, and cardiovascular diseases.
白藜芦醇（Res）是一种存在于红酒中的多酚，已被证明可以延缓衰老，即生理完整性和细胞衰老的逐渐丧失，其特征是无法通过细胞周期。在人类中，还没有完成关于剂量限制的成功临床试验。然而，Res 在几种体内动物模型中的强大抗衰老和抗衰老功效已被记录在案。在这篇综述中，我们强调了 Res 在抗衰老疾病（如糖尿病、神经退行性疾病、眼病和心血管疾病）中的功效的分子机制。
