Zaki Farzana, Wang Yahui, Wang Chizhong, Liu Xuan
Dept. of Electrical and Computer Engineering, New Jersey Institute of Technology, University Heights, Newark, New Jersey, USA, 07102.
Proc SPIE Int Soc Opt Eng. 2019 Feb;10880. doi: 10.1117/12.2503809. Epub 2019 Feb 21.
Optical coherence tomography (OCT) allows structural and functional imaging of biological tissue with high resolution and high speed. Optical coherence elastography (OCE), a functional extension of OCT, has been used to perform mechanical characterization. A handheld fiber-optic OCE instrument allows high sensitivity virtual palpation of tissue with great convenience and flexibility and can be used in a wide range of clinical settings. Moreover, fiber-optic OCE instruments can be integrated into a needle device to access deep tissue. However, the major challenge in the development of handheld OCE instrument is non-constant motion within the tissue. In this study, a simple and effective method for temporally and spatially adaptive Doppler analysis is investigated. The adaptive Doppler analysis method strategically chooses the time interval () between signals involved in Doppler analysis, to track the motion speed (,) that varies as time () and depth () in a deformed sample volume under manual compression. The aim is to use an optimal time interval to achieve a large yet artifact free Doppler phase shift for motion tracking.
光学相干断层扫描（OCT）能够以高分辨率和高速对生物组织进行结构和功能成像。光学相干弹性成像（OCE）作为OCT的功能扩展，已被用于进行力学特性分析。手持式光纤OCE仪器能够高度灵敏地对组织进行虚拟触诊，具有极大的便利性和灵活性，可用于广泛的临床场景。此外，光纤OCE仪器可集成到针状设备中以进入深部组织。然而，手持式OCE仪器开发中的主要挑战是组织内的非恒定运动。在本研究中，研究了一种用于时间和空间自适应多普勒分析的简单有效方法。自适应多普勒分析方法策略性地选择多普勒分析中所涉及信号之间的时间间隔（），以跟踪在手动压缩下变形样本体积中随时间（）和深度（）变化的运动速度（，）。目的是使用最佳时间间隔来实现用于运动跟踪的大且无伪影的多普勒相移。
