Qiu Yi, Wang Yahui, Xu Yiqing, Chandra Namas, Haorah James, Hubbi Basil, Pfister Bryan J, Liu Xuan
Department of Electrical and Computer Engineering, New Jersey Institute of Technology, Newark, NJ, 07102, USA.
Department of Electrical and Electronic Engineering, Hong Kong University, Hong Kong, China.
Biomed Opt Express. 2016 Jan 26;7(2):688-700. doi: 10.1364/BOE.7.000688. eCollection 2016 Feb 1.
We developed a miniature quantitative optical coherence elastography (qOCE) instrument with an integrated Fabry-Perot force sensor, for in situ elasticity measurement of biological tissue. The technique has great potential for biomechanics modeling and clinical diagnosis. We designed the fiber-optic qOCE probe that was used to exert a compressive force to deform tissue at the tip of the probe. Using the space-division multiplexed optical coherence tomography (OCT) signal detected by a spectral domain OCT engine, we were able to quantify the probe deformation that was proportional to the force applied, and to quantify the tissue deformation corresponding to the external stimulus. Simultaneous measurement of force and displacement allowed us to extract Young's modulus of biological tissue. We experimentally calibrated our qOCE instrument, and validated its effectiveness on tissue mimicking phantoms and biological tissues.
我们开发了一种带有集成法布里-珀罗力传感器的微型定量光学相干弹性成像（qOCE）仪器，用于生物组织的原位弹性测量。该技术在生物力学建模和临床诊断方面具有巨大潜力。我们设计了光纤qOCE探头，用于施加压缩力使探头尖端的组织变形。利用光谱域光学相干断层扫描（OCT）引擎检测到的空分复用光学相干断层扫描（OCT）信号，我们能够量化与施加力成比例的探头变形，并量化对应于外部刺激的组织变形。同时测量力和位移使我们能够提取生物组织的杨氏模量。我们通过实验校准了我们的qOCE仪器，并在组织模拟体模和生物组织上验证了其有效性。
