关于AAA和AcurosXB算法在三种不同的立体定向消融体部放射治疗（SABR）技术中的应用：容积调强弧形放疗（VMAT）、调强放射治疗（IMRT）和三维适形放疗（3D-CRT）。
On the use of AAA and AcurosXB algorithms for three different stereotactic ablative body radiotherapy (SABR) techniques: Volumetric modulated arc therapy (VMAT), intensity modulated radiation therapy (IMRT) and 3D conformal radiotherapy (3D-CRT).
作者信息
Tajaldeen Abdulrahman, Ramachandran Prabhakar, Alghamdi Salem, Geso Moshi
机构信息
School of Health & Biomedical Sciences, RMIT University, Victoria, Australia.
Peter MacCallum cancer centre, Victoria, Australia.
出版信息
Rep Pract Oncol Radiother. 2019 Jul-Aug;24(4):399-408. doi: 10.1016/j.rpor.2019.02.008. Epub 2019 Mar 23.
AIM
The purpose of this study was to investigate the dosimetric characteristics of three stereotactic ablative body radiotherapy (SABR) techniques using the anisotropic analytical algorithm (AAA) and Acuros XB algorithm. The SABR techniques include coplanar volumetric modulated arc therapy (C-VMAT), non-coplanar intensity modulated radiation therapy (NC-IMRT) and non-coplanar three-dimensional conformal radiotherapy (NC-3D CRT).
BACKGROUND
SABR is a special type of radiotherapy where a high dose of radiation is delivered over a short time. The treatment outcome and accuracy of the dose delivered to cancer patients highly depend on the dose calculation algorithm and treatment technique.
MATERIALS AND METHODS
Twelve lung cancer patients underwent 4D CT scanning, and three different treatment plans were generated: C-VMAT, NC-IMRT, NC-3D CRT. Dose calculation was performed using the AAA and Acuros XB algorithm. The dosimetric indices, such as conformity index (CI), homogeneity index, dose fall-off index, doses received by organs at risk and planning target volume, were used to compare the plans. The accuracy of AAA and Acuros XB (AXB) algorithms for the lung was validated against measured dose on a CIRS thorax phantom.
RESULTS
The CIs for C-VMAT, NC-IMRT and NC-3D CRT were 1.21, 1.28 and 1.38 for the AAA, respectively, and 1.17, 1.26 and 1.36 for the Acuros XB algorithm, respectively. The overall dose computed by AcurosXB algorithm was close to the measured dose when compared to the AAA algorithm. The overall dose computed by the AcurosXB algorithm was close to the measured dose when compared to the AAA algorithm.
CONCLUSION
This study showed that the treatment planning results obtained using the Acuros XB algorithm was better than those using the AAA algorithm in SABR lung radiotherapy.
目的
本研究旨在使用各向异性分析算法（AAA）和Acuros XB算法研究三种立体定向消融体部放射治疗（SABR）技术的剂量学特征。SABR技术包括共面容积调强弧形放疗（C-VMAT）、非共面调强放射治疗（NC-IMRT）和非共面三维适形放疗（NC-3D CRT）。
背景
SABR是一种特殊类型的放射治疗，在短时间内给予高剂量辐射。输送给癌症患者的治疗结果和剂量准确性高度依赖于剂量计算算法和治疗技术。
材料与方法
12例肺癌患者接受4D CT扫描，并生成三种不同的治疗计划：C-VMAT、NC-IMRT、NC-3D CRT。使用AAA和Acuros XB算法进行剂量计算。使用剂量学指标，如适形指数（CI）、均匀性指数、剂量跌落指数、危及器官和计划靶体积所接受的剂量，来比较这些计划。在CIRS胸部体模上，根据测量剂量验证AAA和Acuros XB（AXB）算法对肺部的准确性。
结果
对于AAA算法，C-VMAT、NC-IMRT和NC-3D CRT的CI分别为1.21、1.28和1.38，对于Acuros XB算法，分别为1.17、1.26和1.36。与AAA算法相比，Acuros XB算法计算的总体剂量更接近测量剂量。与AAA算法相比，Acuros XB算法计算的总体剂量更接近测量剂量。
结论
本研究表明，在SABR肺部放射治疗中，使用Acuros XB算法获得的治疗计划结果优于使用AAA算法的结果。
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