Khattar M M, Salt W G, Stretton R J
Department of Chemistry, Loughborough University of Technology, Leicestershire, UK.
J Appl Bacteriol. 1988 Mar;64(3):265-72. doi: 10.1111/j.1365-2672.1988.tb03384.x.
Pyrithione was active against a range of micro-organisms, the most resistant being Gram-negative bacteria. The growth curves for Klebsiella pneumoniae and Bacillus licheniformis showed a drug-dependent lag phase. Candida albicans grew with a drug-dependent growth rate. EDTA antagonized the effects of pyrithione.
吡啶硫酮对多种微生物具有活性,其中最具抗性的是革兰氏阴性菌。肺炎克雷伯菌和地衣芽孢杆菌的生长曲线显示出药物依赖性的延迟期。白色念珠菌以药物依赖性生长速率生长。乙二胺四乙酸(EDTA)拮抗吡啶硫酮的作用。