Phan Thanh G, Beare Richard, Srikanth Velandai, Ma Henry
Department of Neurology, Monash Health, Melbourne, VIC, Australia.
Clinical Trials, Imaging and Infomatics (CTI), Division of Stroke and Aging Research Group, Medicine, School of Clinical Sciences, Monash University, Melbourne, VIC, Australia.
Front Neurol. 2019 Jul 2;10:708. doi: 10.3389/fneur.2019.00708. eCollection 2019.
Endovascular clot retrieval (ECR) has revolutionized acute stroke therapy but is expensive to run and staff with accredited interventional neuroradiologists 24/7; consequently, it is only feasible for each metropolitan city to have a minimum number of hubs that is adequate to service the population. This method is applied to search the minimum number of hospitals to be designated as ECR hubs in Sydney as well as the population at risk of stroke reachable within 30 min. Traveling time from the centroids of each suburbs to five ECR capable hubs [Royal Prince Alfred/RPA, Prince of Wales/POW, Royal North Shore/RNS, Liverpool/LH and Westmead/WH]. This step was performed using package in R to interface with Google Map application program interface (API). Next, we calculate the percentage of suburbs within each catchment in which traveling time to the ECR hub is <30 min. This step was performed for all possible combination of ECR hubs. The maps are available at https://gntem3.shinyapps.io/ambsydney/. The population at risk of stroke was estimated using stroke incident studies in Melbourne and Adelaide. The best 3-hospital combinations are LPH/WH/RNS (82.3, 45.7, and 79.7% of suburbs reachable within 30 min or 187 of 226 suburbs) follow by RPA/LPH/RNS (100.0, 80.9, and 73.1% of suburbs) and LPH/POW/RNS (83.3, 90.7, and 76.6% of suburbs). The best 4-hospital model is LPH/WH/POW/RNS (84.2%, 91.1%, 90.7%, 77.8%). In the 5-hospital model, ECR is available for 191 suburbs within 30 min: LPH (83%), RPA (100%), WH (90.2%), RNS (72.7%), POW (88.9%). Based on 3-hospital model and 15% of patient eligible for ECR, the expected number of cases to be handled by each hospital is 465. This number drops down to 374 if a 4-hospital model is preferred. The simulation studies supported a minimum of 4 ECR hubs servicing Sydney. This model provides data on number of suburbs and population at risk of stroke that can reach these hubs within 30 min.
血管内血栓清除术(ECR)彻底改变了急性中风治疗方式,但运行成本高昂,且需要配备经过认证的介入神经放射科医生全天候值班;因此,每个大城市只设立最少数量的足以服务当地人口的中心才可行。此方法用于搜索悉尼被指定为ECR中心的最少医院数量,以及30分钟内可抵达的中风高危人群。计算从每个郊区中心到五个具备ECR能力的中心[皇家阿尔弗雷德王子医院/RPA、威尔士王子医院/POW、皇家北岸医院/RNS、利物浦医院/LH和韦斯特米德医院/WH]的出行时间。这一步骤使用R语言中的包与谷歌地图应用程序编程接口(API)进行交互来完成。接下来,我们计算每个集水区内出行时间到ECR中心小于30分钟的郊区百分比。这一步骤针对ECR中心的所有可能组合进行。地图可在https://gntem3.shinyapps.io/ambsydney/获取。中风高危人群是根据墨尔本和阿德莱德的中风发病研究估算的。最佳的三医院组合是利物浦医院/LH/韦斯特米德医院/WH/皇家北岸医院/RNS(30分钟内可抵达的郊区占比分别为82.3%、45.7%和79.7%,即226个郊区中的187个),其次是皇家阿尔弗雷德王子医院/RPA/利物浦医院/LH/皇家北岸医院/RNS(分别为100.0%、80.9%和73.1%的郊区)以及利物浦医院/LH/威尔士王子医院/POW/皇家北岸医院/RNS(分别为83.3%、90.7%和76.6%的郊区)。最佳的四医院模式是利物浦医院/LH/韦斯特米德医院/WH/威尔士王子医院/POW/皇家北岸医院/RNS(分别为84.2%、91.1%、90.7%、77.8%)。在五医院模式中,30分钟内191个郊区可进行ECR:利物浦医院/LH(83%)、皇家阿尔弗雷德王子医院/RPA(100%)、韦斯特米德医院/WH(90.2%)、皇家北岸医院/RNS(72.7%)、威尔士王子医院/POW(88.9%)。基于三医院模式以及15%符合ECR条件的患者,每家医院预计处理的病例数为465例。如果选择四医院模式,这个数字会降至374例。模拟研究支持悉尼至少需要4个ECR中心。该模型提供了30分钟内可抵达这些中心的郊区数量和中风高危人群的数据。