绝经后女性的炎症标志物与骨骼健康：横断面综述
Inflammatory markers and bone health in postmenopausal women: a cross-sectional overview.
作者信息
Ilesanmi-Oyelere Bolaji Lilian, Schollum Linda, Kuhn-Sherlock Barbara, McConnell Michelle, Mros Sonya, Coad Jane, Roy Nicole C, Kruger Marlena Cathorina
机构信息
1Department of Nutritional Science, School of Food and Advanced Technology, College of Sciences, Massey University, Tennent Drive, Palmerston North, 4442 New Zealand.
2Riddet Institute, Palmerston North, 4442 New Zealand.
出版信息
Immun Ageing. 2019 Jul 10;16:15. doi: 10.1186/s12979-019-0155-x. eCollection 2019.
BACKGROUND
Cytokines, chemokines, C-reactive proteins (CRP) and ferritin are known inflammatory markers. However, cytokines such as interleukin (IL-1β), (IL-6) and tumour necrosis factor (TNF-α) have been reported to interfere with both the bone resorption and bone formation processes. Similarly, immune cell cytokines are known to contribute to inflammation of the adipose tissue especially with obesity. IL-10 but not IL-33 has been linked to lower ferritin levels and anemia. In this study, we hypothesized that specific cytokine levels in the plasma of women with low bone mineral density (BMD) would be higher than those in the plasma of healthy women due to the actions of elevated levels of pro-inflammatory cytokines in inducing osteoclast formation and differentiation during senescence.
RESULTS
Levels of cytokines (IFNα2, IFN-γ, IL-12p70, IL-33) and monocyte chemoattractant protein-1 (MCP-1) were significantly higher in the plasma of the osteoporotic group compared to the osteopenic and/or healthy groups. Meanwhile CRP levels were significantly lower in women with osteoporosis ( = 0.040) than the osteopenic and healthy groups. Hip BMD values were significantly lower in women with high/detectable values of IL-1β ( = 0.020) and IL-6 ( = 0.030) compared to women where these were not detected. Similarly, women with high/detectable values of IL-1β had significantly lower spine BMD than those where IL-1β was not detected ( = 0.030). Participants' CRP levels were significantly positively correlated with BMI, fat mass and fat percentage ( < 0.001). In addition, ferritin levels of women with high/detectable values of anti-osteoclastogenic IL-10 ( = 0.012) and IL-33 ( = 0.017) were significantly lower than those where these were not detected. There was no statistically significant association between TNF-α and BMD of the hip and lumbar spine.
CONCLUSIONS
High levels of cytokines (IFNα2, IFN-γ, IL-12p70, IL-33) and MCP-1 in apparently healthy postmenopausal women are associated with bone health issues. In addition, an increase in levels of IL-10 and IL-33 may be associated with low ferritin levels in this age group.
TRIAL REGISTRATION
ANZCTR, ACTRN12617000802303. Registered May 31st, 2017, https://www.anzctr.org.au/Trial/Registration/TrialReview.aspx?id=373020.
背景
细胞因子、趋化因子、C反应蛋白（CRP）和铁蛋白是已知的炎症标志物。然而，据报道，白细胞介素（IL-1β）、（IL-6）和肿瘤坏死因子（TNF-α）等细胞因子会干扰骨吸收和骨形成过程。同样，免疫细胞细胞因子已知会导致脂肪组织炎症，尤其是在肥胖情况下。IL-10而非IL-33与较低的铁蛋白水平和贫血有关。在本研究中，我们假设骨密度低（BMD）的女性血浆中特定细胞因子水平会高于健康女性血浆中的水平，这是由于衰老过程中促炎细胞因子水平升高在诱导破骨细胞形成和分化方面的作用。
结果
与骨量减少和/或健康组相比，骨质疏松组血浆中的细胞因子（IFNα2、IFN-γ、IL-12p70、IL-33）和单核细胞趋化蛋白-1（MCP-1）水平显著更高。同时，骨质疏松女性的CRP水平（=0.040）显著低于骨量减少和健康组。与未检测到IL-1β（=0.020）和IL-6（=0.030）的女性相比，IL-1β和IL-6高值/可检测值的女性髋部骨密度值显著更低。同样，IL-1β高值/可检测值的女性脊柱骨密度显著低于未检测到IL-1β的女性（=0.030）。参与者的CRP水平与体重指数、脂肪量和脂肪百分比显著正相关（<0.001）。此外，抗破骨细胞生成的IL-10（=0.012）和IL-33（=0.017）高值/可检测值的女性铁蛋白水平显著低于未检测到这些的女性。TNF-α与髋部和腰椎骨密度之间无统计学显著关联。
结论
明显健康的绝经后女性中高水平的细胞因子（IFNα2、IFN-γ、IL-12p70、IL-33）和MCP-1与骨骼健康问题相关。此外，IL-10和IL-33水平升高可能与该年龄组的低铁蛋白水平有关。
试验注册
澳大利亚和新西兰临床试验注册中心，ACTRN12617000802303。2017年5月31日注册，https://www.anzctr.org.au/Trial/Registration/TrialReview.aspx?id=373020。
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