播散性脑曲霉病合并血栓性微血管病。
Disseminated cerebral aspergillosis complicated by thrombotic microangiopathy.
作者信息
Lester Robynn, Church Deirdre, Ambasta Anshula
机构信息
Cumming School of Medicine, University of Calgary, Calgary, Alberta, Canada.
Department of Pathology & Laboratory Medicine and Medicine, University of Calgary, Calgary, Alberta, Canada.
出版信息
Med Mycol Case Rep. 2019 Jul 5;25:25-28. doi: 10.1016/j.mmcr.2019.07.002. eCollection 2019 Sep.
Invasive aspergillosis (IA) is a serious condition that can affect almost any organ. Cerebral aspergillosis itself is rapidly fatal without treatment. We report a case of disseminated cerebral IA in a patient exposed to cyclophosphamide, rituximab and prednisone. This case is unique because: 1) disseminated IA has not been described in anti-glomerular basement membrane glomerulonephritis; 2) IA led to thrombotic microangiopathy with normal ADAMTS13 and 3) voriconazole toxicity necessitated use of isavuconazole for IA treatment.
侵袭性曲霉病（IA）是一种严重疾病，几乎可累及任何器官。脑曲霉病若不治疗本身会迅速致命。我们报告一例暴露于环磷酰胺、利妥昔单抗和泼尼松的患者发生播散性脑IA的病例。该病例独特之处在于：1）抗肾小球基底膜肾小球肾炎中尚未描述过播散性IA；2）IA导致血栓性微血管病，而ADAMTS13正常；3）伏立康唑毒性使得必须使用艾沙康唑治疗IA。
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