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采用基质诱导自体软骨细胞植入曲奇切割技术治疗软骨缺损

Treatment of Cartilage Defects With the Matrix-Induced Autologous Chondrocyte Implantation Cookie Cutter Technique.

作者信息

Hevesi Mario, Krych Aaron J, Saris Daniel B F

机构信息

Department of Orthopedic Surgery and Sports Medicine, Mayo Clinic, Rochester, Minnesota, U.S.A.

出版信息

Arthrosc Tech. 2019 May 16;8(6):e591-e596. doi: 10.1016/j.eats.2019.01.022. eCollection 2019 Jun.

DOI:10.1016/j.eats.2019.01.022
PMID:31334015
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC6624120/
Abstract

Focal cartilage defects lead to significant pain and disability, prompting the development of various options for biologic restoration of the articular surface. Although each technique and biologic implant provides various advantages and associated limitations, matrix-induced autologous chondrocyte implantation (MACI) has gained popularity given promising long-term results. We present a technique for the facile implantation of MACI membranes using cookie cutter instrumentation to aid in defect debridement and graft preparation. The technique described allows for efficient operative workflow while ensuring the creation of vertical, stable defect edges and a form-fitting MACI membrane in a readily implemented fashion.

摘要

局灶性软骨缺损会导致严重疼痛和功能障碍，促使人们开发各种用于关节表面生物修复的方法。尽管每种技术和生物植入物都有各自的优点和相关局限性，但鉴于其长期效果良好，基质诱导自体软骨细胞植入术（MACI）已受到广泛关注。我们介绍一种使用曲奇刀器械简便植入MACI膜的技术，该技术有助于缺损清创和移植物制备。所描述的技术可实现高效的手术流程，同时确保形成垂直、稳定的缺损边缘，并以易于实施的方式制备贴合缺损形状的MACI膜。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/2e6c/6624120/bbd6cda230f3/gr14.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/2e6c/6624120/f742ee6e7ac5/gr1.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/2e6c/6624120/0c6bb472f11b/gr2.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/2e6c/6624120/4dca6e57dfb0/gr3.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/2e6c/6624120/63e869842ce7/gr4.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/2e6c/6624120/562a2502a978/gr5.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/2e6c/6624120/e489b9d15010/gr6.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/2e6c/6624120/294435e6b853/gr7.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/2e6c/6624120/5fea28a993ae/gr8.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/2e6c/6624120/aa33342d5644/gr9.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/2e6c/6624120/5d075f4a5b0d/gr10.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/2e6c/6624120/a94fd1279a2d/gr11.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/2e6c/6624120/4cc2264d74ec/gr12.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/2e6c/6624120/90f4d3d0a5bf/gr13.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/2e6c/6624120/bbd6cda230f3/gr14.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/2e6c/6624120/f742ee6e7ac5/gr1.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/2e6c/6624120/0c6bb472f11b/gr2.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/2e6c/6624120/4dca6e57dfb0/gr3.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/2e6c/6624120/63e869842ce7/gr4.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/2e6c/6624120/562a2502a978/gr5.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/2e6c/6624120/e489b9d15010/gr6.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/2e6c/6624120/294435e6b853/gr7.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/2e6c/6624120/5fea28a993ae/gr8.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/2e6c/6624120/aa33342d5644/gr9.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/2e6c/6624120/5d075f4a5b0d/gr10.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/2e6c/6624120/a94fd1279a2d/gr11.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/2e6c/6624120/4cc2264d74ec/gr12.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/2e6c/6624120/90f4d3d0a5bf/gr13.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/2e6c/6624120/bbd6cda230f3/gr14.jpg

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