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血流动力学早期目标导向治疗:解读细则

Hemodynamic early goal-directed therapy: Explaining the fine print.

作者信息

Goldthwaite Zoe, Firstenberg Michael S, Botsch Alex

机构信息

Department of Cardiothoracic and Vascular Surgery, The Medical Center of Aurora, Aurora, CO, USA.

Department of Critical Care Medicine, Summa Akron City Hospital, Akron, OH, USA.

出版信息

Int J Crit Illn Inj Sci. 2019 Apr-Jun;9(2):54-56. doi: 10.4103/IJCIIS.IJCIIS_38_19.

Abstract

The management of patients after cardiothoracic surgery can be very complex. Variabilities exist in hemodynamic status after cardiac surgery and the use of cardiopulmonary bypass - all of which can have a significant impact on myocardial Frank-Starling curves. Typically, invasive monitoring with pulmonary artery catheters is used to assess the complex physiology that these patients experience in the perioperative setting. However, the use of invasive monitoring is not without risk, and the broader benefits are poorly defined. Furthermore, there is growing evidence to support the use of hemodynamic early goal-directed therapy to optimize outcomes in critically ill patients. The purpose of this editorial statement is the review of some of the current literature with regards to the utility of goal-directed therapy as applied to the postoperative cardiac surgical patient.

摘要

心胸外科手术后患者的管理可能非常复杂。心脏手术后的血流动力学状态以及体外循环的使用存在差异,所有这些都会对心肌的Frank-Starling曲线产生重大影响。通常,使用肺动脉导管进行有创监测来评估这些患者在围手术期所经历的复杂生理状况。然而,有创监测并非没有风险,其更广泛的益处也不明确。此外,越来越多的证据支持使用血流动力学早期目标导向治疗来优化危重症患者的治疗效果。本社论声明的目的是回顾一些关于目标导向治疗应用于心脏外科术后患者效用的当前文献。

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本文引用的文献

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Goal-directed therapy: hit early and personalize!目标导向治疗:尽早出击并实现个性化!
J Clin Monit Comput. 2018 Jun;32(3):375-377. doi: 10.1007/s10877-017-0043-x. Epub 2017 Jun 26.
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Trial of early, goal-directed resuscitation for septic shock.早期目标导向性复苏治疗脓毒性休克的试验。
N Engl J Med. 2015 Apr 2;372(14):1301-11. doi: 10.1056/NEJMoa1500896. Epub 2015 Mar 17.
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Goal-directed resuscitation for patients with early septic shock.目标导向性复苏治疗早期感染性休克患者。
N Engl J Med. 2014 Oct 16;371(16):1496-506. doi: 10.1056/NEJMoa1404380. Epub 2014 Oct 1.

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