Gupta Sanjeev, Pruthi Sahil, Kumar Ajay, Mahendra Aneet
Department of Dermatology, Venereology and Leprology, Maharishi Markandeshwar Institute of Medical Sciences and Research, Mullana, Ambala, Haryana, India.
Department of Dermatology, Venereology and Leprology, Dr D Y Patil Medical College, Hospital and Research Centre, Pimpri, Pune, Maharashtra, India.
Indian Dermatol Online J. 2019 Jul-Aug;10(4):396-400. doi: 10.4103/idoj.IDOJ_376_18.
Chronic and recurrent vesiculation over the palms and soles is termed chronic vesicular dermatitis. Its etiology is multifactorial and contact allergy plays an important role.
The aim of the study is to evaluate the clinical relevance of patch test reactivity to common contact allergens in chronic palmoplantar vesicular dermatitis.
An observational study was conducted enrolling 152 patients of chronic palmoplantar vesicular dermatitis. Patch testing was carried out with the Indian Standard Battery and also with the materials used by patients. Statistical analysis was carried out using SPSS software.
Among 152 patients, 91 were female and 61 male. The peak incidence was in the 14-24 years age group. Their occupations included housewives 48, laborers 26, factory workers 16, farm workers 14, and shopkeepers 12. Patch tests were positive in 79 (52%) patients, including 43 (28.3%) female and 36 (23.7%) male. Patch test reactivity was observed with nickel in 25 (16.4%); potassium dichromate in 21 (13.8%); fragrance mix in 17 (11.2%); -phenylenediamine in 14 (9.2%); black rubber in 10 (6.6%); mercaptobenzothiazole in 8 (5.3%); and parthenium in 8 (5.3%) patients. Clinical relevance of positive patch tests was determined in 47 (59.5%) patients.
Though patch test reactivity was higher in females as compared with males, the difference was not statistically significant. Clinical relevance of positive patch tests was established with nickel in 9 (19.1%) patients; antigens associated with rubber including black rubber, mercaptobenzothiazole, and thiuram mix in 7 (14.9%); potassium dichromate in 7 (14.9%); -phenylenediamine in 6 (12.8%); and parthenium in 4 (8.5%) patients.
手掌和脚底反复出现慢性水疱被称为慢性水疱性皮炎。其病因是多因素的，接触性过敏起重要作用。
本研究旨在评估慢性掌跖水疱性皮炎患者对常见接触性变应原的斑贴试验反应的临床相关性。
进行一项观察性研究，纳入152例慢性掌跖水疱性皮炎患者。采用印度标准试剂组以及患者使用的材料进行斑贴试验。使用SPSS软件进行统计分析。
152例患者中，女性91例，男性61例。发病高峰年龄在14 - 24岁组。其职业包括家庭主妇48例、劳动者26例、工厂工人16例、农场工人14例、店主12例。79例（52%）患者斑贴试验呈阳性，其中女性43例（28.3%），男性36例（23.7%）。25例（16.4%）患者对镍斑贴试验有反应；21例（13.8%）对重铬酸钾有反应；17例（11.2%）对香料混合物有反应；14例（9.2%）对对苯二胺有反应；10例（6.6%）对黑色橡胶有反应；8例（5.3%）对巯基苯并噻唑有反应；8例（5.3%）对银胶菊有反应。47例（59.5%）患者确定了斑贴试验阳性的临床相关性。
虽然女性斑贴试验反应性高于男性，但差异无统计学意义。9例（19.1%）患者确定镍斑贴试验阳性具有临床相关性；7例（14.9%）患者确定与橡胶相关的抗原（包括黑色橡胶、巯基苯并噻唑和秋兰姆混合物）具有临床相关性；7例（14.9%）患者确定重铬酸钾具有临床相关性；6例（12.8%）患者确定对苯二胺具有临床相关性；4例（8.5%）患者确定银胶菊具有临床相关性。
