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印度抗菌药物耐药性国家行动计划——背景、现状及未来方向概述

India's National Action Plan for antimicrobial resistance - An overview of the context, status, and way ahead.

作者信息

Ranjalkar Jaya, Chandy Sujith J

机构信息

Department of Pharmacology and Clinical Pharmacology, Christian Medical College and Hospital, Vellore, Tamil Nadu, India.

出版信息

J Family Med Prim Care. 2019 Jun;8(6):1828-1834. doi: 10.4103/jfmpc.jfmpc_275_19.

Abstract

Antimicrobial resistance (AMR) is a multifaceted complex problem with momentous consequences for individuals as well as health-care systems. Understanding the gravity of the problem, the World Health Assembly has adopted the Global Action Plan on AMR in the year 2015 as a part of the tripartite collaboration with World Health Organization, Food and Agricultural Organization, and World Organization for Animal Health. India's National Action Plan (NAP) for AMR was released in April 2017 by the Union Ministry of Health and Family Welfare. The objectives of the NAP include improving awareness, enhancing surveillance measures, strengthening infection prevention and control, research and development, promoting investments, and collaborative activities to control AMR. On the basis of the NAP, various states have begun the process of initiating their State Action Plans. The aim of this article is to highlight some of the main components of the NAP and to make family physicians, general practitioners, and other stakeholders aware of the issue of AMR and its factors and what can be done. The article also discusses some of the challenges in implementation of NAP such as varied perceptions about antibiotic use and AMR among key stakeholders, inappropriate antibiotic use owing to a number of reasons, lack of diagnostic facilities, widespread use of antibiotics in various sectors, environmental contamination because of pharmaceutical industry, agricultural and hospital waste, gaps in infection prevention and control, and difficulty in enforcing regulations. Similar to other low-middle income countries (LMICs), lack of sufficient finances remains a major challenge in NAP implementation in India as well. Overall, a strong political will, inter-sectoral co-ordination between public and private sectors and comprehensive strengthening of the healthcare systems are necessary to achieve the desired forward momentum.

摘要

抗菌药物耐药性(AMR)是一个多方面的复杂问题,对个人和医疗保健系统都有着重大影响。鉴于认识到该问题的严重性,世界卫生大会于2015年通过了《抗菌药物耐药性全球行动计划》,作为与世界卫生组织、粮食及农业组织和世界动物卫生组织三方合作的一部分。印度卫生部和家庭福利部于2017年4月发布了印度抗菌药物耐药性国家行动计划(NAP)。该国家行动计划的目标包括提高认识、加强监测措施、强化感染预防与控制、研发、促进投资以及开展控制抗菌药物耐药性的合作活动。基于该国家行动计划,各邦已开始启动各自邦行动计划的进程。本文旨在突出该国家行动计划的一些主要组成部分,并使家庭医生、全科医生和其他利益相关者了解抗菌药物耐药性问题及其影响因素以及可以采取的措施。本文还讨论了国家行动计划实施过程中的一些挑战,例如关键利益相关者对抗生素使用和抗菌药物耐药性的不同看法、由于多种原因导致的抗生素使用不当、缺乏诊断设施、抗生素在各个部门的广泛使用、制药行业、农业和医院废物造成的环境污染、感染预防与控制方面的差距以及法规执行困难。与其他中低收入国家(LMICs)类似,资金不足在印度国家行动计划的实施中仍然是一个重大挑战。总体而言,要实现预期的推进势头,需要坚定的政治意愿、公共和私营部门之间的跨部门协调以及医疗保健系统的全面强化。

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