Cheraghi Mostafa, Ahmadvand Hassan, Maleki Ali, Babaeenezhad Esmaeel, Shakiba Salman, Hassanzadeh Fatemeh
Department of Cardiology, Madani Heart Center, Lorestan University of Medical Sciences, Khorramabad, Iran.
Razi Herbal Medicine Research Center, Faculty of Medicine, Lorestan University of Medical Sciences, Khorramabad, Iran.
Rep Biochem Mol Biol. 2019 Apr;8(1):49-55.
Oxidative stress plays an important role in the development of atherosclerosis. An association exists between the alterations of liver markers and the risk of coronary heart disease (CHD). This study was designed to investigate the status of oxidative stress and liver markers in patients with CHD.
This study included 50 CHD patients and 50 healthy volunteers. Serum activities of glutathione peroxidase (GPX), catalase (CAT), alkaline phosphatase (ALP), alanine aminotransferase (ALT), aspartate aminotransferase (AST), and glutathione (GSH), malondialdehyde (MDA), nitric oxide (NO), and fasting blood sugar (FBS) concentrations were measured. The Unpaired Student's t-test was used to analyze the data.
Serum GSH level and CAT and GPX activities were significantly greater in healthy controls than in CHD patients. Serum MDA, NO, and FBS levels and GGT, ALT, ALP activities were significantly greater in CHD patients than in healthy controls. Serum AST activity was greater in CHD patients than in controls, but the difference was not statistically significant.
Our results indicate that CHD is related to oxidative stress, lipid peroxidation, inflammation, and elevated liver enzyme activity. CHD is a deadly disease that requires appropriate medical care. Antioxidant treatment might inhibit disease progression.
氧化应激在动脉粥样硬化的发展过程中起重要作用。肝脏标志物的改变与冠心病（CHD）风险之间存在关联。本研究旨在调查冠心病患者的氧化应激状态和肝脏标志物情况。
本研究纳入50例冠心病患者和50名健康志愿者。检测血清谷胱甘肽过氧化物酶（GPX）、过氧化氢酶（CAT）、碱性磷酸酶（ALP）、丙氨酸氨基转移酶（ALT）、天冬氨酸氨基转移酶（AST）的活性以及谷胱甘肽（GSH）、丙二醛（MDA）、一氧化氮（NO）的水平和空腹血糖（FBS）浓度。采用非配对学生t检验分析数据。
健康对照组的血清GSH水平以及CAT和GPX活性显著高于冠心病患者。冠心病患者的血清MDA、NO和FBS水平以及γ-谷氨酰转移酶（GGT）、ALT、ALP活性显著高于健康对照组。冠心病患者的血清AST活性高于对照组，但差异无统计学意义。
我们的结果表明，冠心病与氧化应激、脂质过氧化、炎症以及肝酶活性升高有关。冠心病是一种致命疾病，需要适当的医疗护理。抗氧化治疗可能会抑制疾病进展。
