Ahmadvand Hassan, Ghasemi-Dehnoo Maryam
Razi Herbal Researches Center AND Department of Biochemistry, School of Medicine, Lorestan University of Medical Sciences, Khorramabad, Iran.
Razi Herbal Researches Center, Lorestan University of Medical Sciences, Khorramabad, Iran.
ARYA Atheroscler. 2014 Jul;10(4):192-8.
Diabetes mellitus, one of the leading metabolic syndromes, accounts for highest morbidity and mortality worldwide. In this study, we examined possible protective effect of coenzyme Q10 on lipid profile, atherogenic index, and liver enzyme markers in alloxan-induced type 1 diabetic rats.
A total of 30 male rats were randomly divided into three groups; group 1 as control, group 2 diabetic untreatment, and group 3 treatments with coenzyme Q10 by 15 mg/kg i.p. daily, respectively .Diabetes was induced in the second and third groups by alloxan injection subcutaneously. After 8 weeks, the levels of fasting blood glucose (FBG), triglyceride (TG), total cholesterol (TC), low density lipoprotein (LDL), very low-density lipoprotein (VLDL), high density lipoprotein (HDL), atherogenic index, atherogenic coefficient, cardiac risk ratio, and the activities of alanine aminotransferase (ALT), aspartate aminotransferase (AST), and alkaline phosphatase (ALP) of all groups were analyzed. Data were analyzed using non-parametric Mann-Whitney test (using SPSS) and P < 0.05 was considered as significant.
Coenzyme Q10 inhibited significantly the activities of ALT (11.17%), AST (19.35%) and ALP (36.67%) and decreased FBG (21.19%), TG (37.24%), TC (17.15%), LDL (30.44%), VLDL (37.24%), atherogenic index (44.24%), atherogenic coefficient (49.69%), and cardiac risk ratio (37.97%), HDL level was significantly (33.38%) increased when treated with coenzyme Q10.
The findings of this study suggest that coenzyme Q10 exert beneficial effects on the lipid profile, atherogenic index, and liver enzymes activity in alloxan-induced type 1 diabetic rats.
糖尿病作为主要的代谢综合征之一，在全球范围内发病率和死亡率最高。在本研究中，我们检测了辅酶Q10对四氧嘧啶诱导的1型糖尿病大鼠血脂谱、动脉粥样硬化指数和肝酶标志物的潜在保护作用。
总共30只雄性大鼠随机分为三组；第一组为对照组，第二组为糖尿病未治疗组，第三组每天腹腔注射15mg/kg辅酶Q10进行治疗。第二组和第三组通过皮下注射四氧嘧啶诱导糖尿病。8周后，分析所有组的空腹血糖（FBG）、甘油三酯（TG）、总胆固醇（TC）、低密度脂蛋白（LDL）、极低密度脂蛋白（VLDL）、高密度脂蛋白（HDL）、动脉粥样硬化指数、动脉粥样硬化系数、心脏风险比以及丙氨酸转氨酶（ALT）、天冬氨酸转氨酶（AST）和碱性磷酸酶（ALP）的活性。使用非参数曼-惠特尼检验（使用SPSS）分析数据，P<0.05被认为具有显著性。
辅酶Q10显著抑制ALT活性（11.17%）、AST活性（19.35%）和ALP活性（36.67%），并降低FBG（21.19%）、TG（37.24%）、TC（17.15%）、LDL（30.44%）、VLDL（37.24%）、动脉粥样硬化指数（44.24%）、动脉粥样硬化系数（49.69%）和心脏风险比（37.97%），当用辅酶Q10治疗时，HDL水平显著升高（33.38%）。
本研究结果表明，辅酶Q10对四氧嘧啶诱导的1型糖尿病大鼠的血脂谱、动脉粥样硬化指数和肝酶活性具有有益作用。
