Ozaki H, Hojo K, Kato H, Kinoshita T, Egawa S, Kishi K
Department of Surgery, National Cancer Center Hospital, Tokyo, Japan.
Int J Pancreatol. 1988 May;3(4):249-59. doi: 10.1007/BF02788454.
Since November 1983, a multidisciplinary protocol for the treatment of pancreatic carcinoma has been used for eight patients at the National Cancer Center Hospital. This therapy includes an extended pancreatic resection, intra-operative irradiation with 3,000 rad of electrons using a microton, and an intra-operative hepatic arterial or portal infusion of mitomycin C, 10 mg. Furthermore, post-operative chemotherapy with mitomycin C (10 mg to 10 mg x 3) is added by Seldinger's method or intravenously (i.v.). The post-operative course was uneventful in all eight patients. Although the number of patients treated is small, the one-year survival rate was 86%. This rate is markedly better than the 28% after conventional radical pancreatectomy from 1962 to 1983. According to our experience, pancreatic carcinoma is unlikely to be cured by only radical operative procedures. A multidisciplinary treatment protocol as an adjunct to radical surgery appears necessary for a good prognosis of this disease.
自1983年11月起，国立癌症中心医院对8例胰腺癌患者采用了多学科治疗方案。该治疗方法包括扩大胰腺切除术、使用微型加速器术中给予3000拉德电子线照射以及术中经肝动脉或门静脉注入10毫克丝裂霉素C。此外，通过塞尔丁格法或静脉注射给予丝裂霉素C（10毫克至10毫克×3）进行术后化疗。8例患者术后过程均顺利。虽然治疗的患者数量较少，但1年生存率为86%。该生存率明显高于1962年至1983年传统根治性胰腺切除术后的28%。根据我们的经验，仅通过根治性手术不太可能治愈胰腺癌。作为根治性手术辅助手段的多学科治疗方案对于该疾病的良好预后似乎是必要的。
