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感染性角膜炎的要点与范例

Pearls and paradigms in Infective Keratitis.

作者信息

Acharya Manisha, Farooqui Javed Hussaina, Jain Shikha, Mathur Umang

机构信息

Dr. Shroff's Charity Eye Hospital, New Delhi, India.

Ram Manohar Lohia Hospital, New Delhi, India.

出版信息

Rom J Ophthalmol. 2019 Apr-Jun;63(2):119-127.

PMID:31334389
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC6626937/
Abstract

Infective Keratitis is a commonly encountered sight-threatening ocular emergency. In developing countries, it is a major cause of corneal blindness. Empirical treatment without microbiological work up often leads to treatment failure. Indiscriminate use of steroid antibiotic combination worsens the situation and makes further management challenging. The correct line of management can be potentially sight saving for both the ophthalmologist and the patient. This article on Infective keratitis has been written keeping best practices and protocols in mind. In a very simple and concise form, it focuses on the salient features of clinical presentation of infective keratitis and the stepwise approach to subsequent management in a patient. It explains in detail the way to perform corneal scraping, the importance of the same and further management based on microbiologically proven result. The management part includes indications and methods for medical as well as surgical intervention. We aimed to share our experience in the management of patients presenting with infective keratitis in the clinic.

摘要

感染性角膜炎是一种常见的、威胁视力的眼部急症。在发展中国家,它是导致角膜盲的主要原因。未经微生物学检查的经验性治疗常常导致治疗失败。不加区分地使用类固醇抗生素联合用药会使情况恶化,并给进一步的治疗带来挑战。正确的治疗方案对眼科医生和患者而言都有可能挽救视力。本文关于感染性角膜炎的撰写遵循了最佳实践和诊疗规范。它以非常简单和简洁的形式,重点介绍了感染性角膜炎临床表现的显著特征以及对患者后续治疗的逐步方法。它详细解释了进行角膜刮片的方法、其重要性以及基于微生物学确诊结果的进一步治疗。治疗部分包括药物及手术干预的适应证和方法。我们旨在分享我们在诊所中管理感染性角膜炎患者的经验。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/640a/6626937/aa9dc20f4f35/RomJOphthalmol-63-119-g006.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/640a/6626937/40906b06e54f/RomJOphthalmol-63-119-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/640a/6626937/950cbc4584da/RomJOphthalmol-63-119-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/640a/6626937/3fdaa091c689/RomJOphthalmol-63-119-g003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/640a/6626937/66d48e169cb7/RomJOphthalmol-63-119-g004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/640a/6626937/c7b84c4798da/RomJOphthalmol-63-119-g005.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/640a/6626937/aa9dc20f4f35/RomJOphthalmol-63-119-g006.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/640a/6626937/40906b06e54f/RomJOphthalmol-63-119-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/640a/6626937/950cbc4584da/RomJOphthalmol-63-119-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/640a/6626937/3fdaa091c689/RomJOphthalmol-63-119-g003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/640a/6626937/66d48e169cb7/RomJOphthalmol-63-119-g004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/640a/6626937/c7b84c4798da/RomJOphthalmol-63-119-g005.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/640a/6626937/aa9dc20f4f35/RomJOphthalmol-63-119-g006.jpg

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本文引用的文献

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Non-contact lens related keratitis.非隐形眼镜相关性角膜炎
Indian J Ophthalmol. 2017 Nov;65(11):1079-1086. doi: 10.4103/ijo.IJO_826_17.
2
Microbial Profile of Corneal Ulcers in a Tertiary Care Hospital in South India.印度南部一家三级护理医院角膜溃疡的微生物学特征
J Ophthalmic Vis Res. 2016 Oct-Dec;11(4):363-367. doi: 10.4103/2008-322X.194071.
3
Clinical efficacy of oral and topical acyclovir in herpes simplex virus stromal necrotizing keratitis.口服和局部应用阿昔洛韦治疗单纯疱疹病毒性基质坏死性角膜炎的临床疗效
中国北方微生物性角膜炎的直接成本分析:一项基于医院的回顾性研究
Pathogens. 2024 Aug 7;13(8):666. doi: 10.3390/pathogens13080666.
4
Whole Genome Sequencing Highlights the Pathogenic Profile in Nocardia Keratitis.全基因组测序凸显诺卡氏菌角膜炎的致病特征。
Invest Ophthalmol Vis Sci. 2024 Mar 5;65(3):26. doi: 10.1167/iovs.65.3.26.
5
A Review of the Categorizations of Mild, Moderate, and Severe Bacterial Keratitis Ulcers and Day-1 Treatment Regimen When Using the Topical Fluoroquinolones 0.3% Ciprofloxacin and 0.3% Ofloxacin.0.3%环丙沙星和0.3%氧氟沙星局部应用时轻度、中度和重度细菌性角膜溃疡的分类及首日治疗方案综述
Curr Ther Res Clin Exp. 2023 Nov 17;99:100729. doi: 10.1016/j.curtheres.2023.100729. eCollection 2023.
6
Evaluation of liposomal amphotericin B for the treatment of fungal keratitis in a tertiary eye care hospital.评价两性霉素 B 脂质体治疗三级眼科医院真菌性角膜炎的效果。
Indian J Ophthalmol. 2023 Feb;71(2):518-523. doi: 10.4103/ijo.IJO_1474_22.
7
Keratitis following leech therapy for periocular eczematous dermatitis: a case report.眼周湿疹性皮炎行水蛭疗法后出现角膜炎:病例报告。
BMC Complement Med Ther. 2023 Jan 2;23(1):124. doi: 10.1186/s12906-022-03613-1.
8
A rare case of Curtobacterium flaccumfaciens infection in the eye: a case report.眼部弗氏短小杆菌感染1例罕见病例报告
Trop Med Health. 2022 Sep 5;50(1):64. doi: 10.1186/s41182-022-00452-1.
9
Toxic non-inflammatory fungal keratitis.毒性非炎性真菌性角膜炎
Indian J Ophthalmol. 2022 May;70(5):1578-1581. doi: 10.4103/ijo.IJO_2509_21.
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Corneal Changes in Acanthamoeba Keratitis at Various Levels of Severity: An In Vivo Confocal Microscopic Study.棘阿米巴角膜炎不同严重程度的角膜改变:体内共聚焦显微镜研究。
Transl Vis Sci Technol. 2021 Jun 1;10(7):10. doi: 10.1167/tvst.10.7.10.
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4
Multidrug-Resistant Pseudomonas aeruginosa Keratitis: Risk Factors, Clinical Characteristics, and Outcomes.多重耐药铜绿假单胞菌角膜炎:危险因素、临床特征和结局。
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5
Ocular Surface as Barrier of Innate Immunity.眼表作为先天性免疫的屏障
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9
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Ophthalmology. 2008 Nov;115(11):1998-2003. doi: 10.1016/j.ophtha.2008.04.038. Epub 2008 Jun 24.
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Association between cultures of contact lens and corneal scraping in contact lens related microbial keratitis.隐形眼镜相关微生物性角膜炎中隐形眼镜培养物与角膜刮片之间的关联
Arch Ophthalmol. 2007 Sep;125(9):1182-5. doi: 10.1001/archopht.125.9.1182.