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抗CD2单克隆抗体对大鼠T淋巴细胞的激活作用。

Activation of rat T lymphocytes by anti-CD2 monoclonal antibodies.

作者信息

Clark S J, Law D A, Paterson D J, Puklavec M, Williams A F

机构信息

Medical Research Council Cellular Immunology Research Unit, Sir William Dunn School of Pathology, Oxford, England.

出版信息

J Exp Med. 1988 Jun 1;167(6):1861-72. doi: 10.1084/jem.167.6.1861.

DOI:10.1084/jem.167.6.1861
PMID:3133442
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC2189691/
Abstract

Rat T cells and thymocytes were induced to proliferate by a pair of mAbs, MRC OX-54 and MRC OX-55, directed against rat CD2. Accessory cells were required but their role was not simply for crosslinking of the two mAbs, as neither MRC OX-54 nor MRC OX-55 alone, in the presence of a crosslinking second antibody, caused T cell mitogenesis. Nor could the phorbol ester PMA replace either antibody. The two mAbs recognized distinct epitopes on rat CD2; however, MRC OX-54 could partially block MRC OX-55 binding whereas the reverse situation was not seen. A further CD2 epitope was recognized by two mutually competitive mAbs, MRC OX-34 and MRC OX-53, which were not mitogenic. Neither MRC OX-34 nor MRC OX-53 affected the binding of MRC OX-54 or MRC OX-55, yet they prevented the mitogenic effect induced by these mAbs. The presence of mAbs against CD4 and the IL-2-R also abrogated this mitogenesis, whereas an anti-CD5 mAb augmented the CD2-induced proliferation.

摘要

一对针对大鼠CD2的单克隆抗体MRC OX - 54和MRC OX - 55可诱导大鼠T细胞和胸腺细胞增殖。需要辅助细胞，但它们的作用不仅仅是使这两种单克隆抗体发生交联，因为在存在交联二抗的情况下，单独的MRC OX - 54或MRC OX - 55都不会引起T细胞有丝分裂。佛波酯PMA也不能替代任何一种抗体。这两种单克隆抗体识别大鼠CD2上不同的表位；然而，MRC OX - 54可部分阻断MRC OX - 55的结合，而反之则未观察到。另外一个CD2表位被两种相互竞争的非促有丝分裂单克隆抗体MRC OX - 34和MRC OX - 53识别。MRC OX - 34和MRC OX - 53都不影响MRC OX - 54或MRC OX - 55的结合，但它们可阻止这些单克隆抗体诱导的促有丝分裂效应。抗CD4和抗IL - 2 - R单克隆抗体的存在也消除了这种有丝分裂，而抗CD5单克隆抗体则增强了CD2诱导的增殖。

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本文引用的文献

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Preparation of monoclonal antibodies: strategies and procedures.单克隆抗体的制备：策略与程序
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Two subsets of rat T lymphocytes defined with monoclonal antibodies.用单克隆抗体定义的大鼠T淋巴细胞的两个亚群。
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Quantitative studies of natural immunity to solid tumours in rats. Persistence of natural immunity throughout reproductive life, and absence of suppressor cells in infant rats.大鼠对实体瘤天然免疫的定量研究。整个生殖期天然免疫的持续性，以及幼鼠中抑制细胞的缺失。
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MRC OX-19: a monoclonal antibody that labels rat T lymphocytes and augments in vitro proliferative responses.MRC OX-19：一种标记大鼠T淋巴细胞并增强体外增殖反应的单克隆抗体。
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