Suea-Ngam Akkapol, Howes Philip D, Srisa-Art Monpichar, deMello Andrew J
Institute for Chemical and Bioengineering, Department of Chemistry and Applied Biosciences, ETH Zürich, Vladimir-Prelog-Weg 1, 8093 Zürich, Switzerland.
Electrochemistry and Optical Spectroscopy Center of Excellence, Department of Chemistry, Faculty of Science, Chulalongkorn University, Patumwan, Bangkok, 10330, Thailand.
Chem Commun (Camb). 2019 Aug 28;55(67):9895-9903. doi: 10.1039/c9cc04750f. Epub 2019 Jul 23.
Droplet microfluidics constitutes a diverse and practical tool set that enables chemical and biological experiments to be performed at high speed and with enhanced efficiency when compared to conventional instrumentation. Indeed, in recent years, droplet-based microfluidic tools have been used to excellent effect in a range of applications, including materials synthesis, single cell analysis, RNA sequencing, small molecule screening, in vitro diagnostics and tissue engineering. Our 2011 Chemical Communications Highlight Article [Chem. Commun., 2011, 47, 1936-1942] reviewed some of the most important technological developments and applications of droplet microfluidics, and identified key challenges that needed to be addressed in the short term. In the current contribution, we consider the intervening eight years, and assess the contributions that droplet-based microfluidics has made to experimental science in its broadest sense.
与传统仪器相比，液滴微流控技术构成了一套多样且实用的工具集，能够实现高速且高效的化学和生物学实验。事实上，近年来，基于液滴的微流控工具已在一系列应用中发挥了出色的作用，包括材料合成、单细胞分析、RNA测序、小分子筛选、体外诊断和组织工程。我们2011年发表在《化学通讯》上的亮点文章[《化学通讯》，2011年，第47卷，第1936 - 1942页]回顾了液滴微流控技术的一些最重要的技术发展和应用，并确定了短期内需要解决的关键挑战。在本论文中，我们回顾了其间的八年，并评估了基于液滴的微流控技术对广义实验科学所做出的贡献。
