Coates Margaret, Patel Jigar, Powers Courtney, Burton Claude
J Drugs Dermatol. 2019 Jul 1;18(7):663-665.
Recalcitrant plantar warts pose a therapeutic challenge. Cidofovir is a viral DNA polymerase inhibitor that has been used in treatment of verrucae with greater success than traditional treatments in some cases. Laser-assisted drug delivery enhances drug penetration beyond the epidermis and is particularly well-suited, though under-utilized, to target palmoplantar verrucae. We report the use of an erbium:yttrium-aluminum-garnet (Er:YAG) ablative fractional laser (AFL) followed by topical cidofovir in treating recalcitrant plantar warts. Two patients were treated with a 2940-nm Er:YAG laser at depths of 1.2-1.5 mm followed by topical application of cidofovir 75 mg/mL. Both patients exhibited a significant reduction in lesion size and improvement in symptoms. AFL-assisted delivery of topical cidofovir represents a promising therapeutic option for recalcitrant plantar warts. J Drugs Dermatol. 2019;18(7):663-665.
顽固性跖疣带来了治疗挑战。西多福韦是一种病毒DNA聚合酶抑制剂，在某些情况下，它用于治疗疣的效果比传统治疗方法更好。激光辅助给药可增强药物穿透表皮的能力，对于靶向治疗掌跖疣特别适用，尽管目前未得到充分利用。我们报告了使用铒：钇铝石榴石（Er：YAG）消融性分数激光（AFL），随后局部应用西多福韦来治疗顽固性跖疣。两名患者接受了波长为2940 nm的Er：YAG激光治疗，深度为1.2 - 1.5 mm，随后局部应用75 mg/mL的西多福韦。两名患者的皮损大小均显著减小，症状也有所改善。AFL辅助局部应用西多福韦是治疗顽固性跖疣的一种有前景的治疗选择。《药物皮肤病学杂志》。2019年；18（7）：663 - 665。
