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表位印迹介孔硅纳米颗粒用于酪氨酸磷酸化的特异性识别。

Epitope-imprinted mesoporous silica nanoparticles for specific recognition of tyrosine phosphorylation.

机构信息

Key Laboratory Molecular Enzymology and Engineering, the Ministry of Education, National Engineering Laboratory of AIDS Vaccine, School of Life Sciences, Jilin University, Changchun 130023, China.

出版信息

Chem Commun (Camb). 2019 Aug 15;55(67):9927-9930. doi: 10.1039/c9cc03950c.

DOI:10.1039/c9cc03950c
PMID:31334708
Abstract

Tyrosine phosphorylation regulates the upstream signaling pathway but accounts for less than 0.1% of total phosphorylation in human cells. Herein, molecularly imprinted mesoporous materials were first synthesized to recognize the phosphorylated tyrosine residue from other phosphorylated residues.

摘要

酪氨酸磷酸化调节上游信号通路，但在人体细胞总磷酸化中所占比例不到 0.1%。本文首次合成了分子印迹介孔材料，以识别磷酸化酪氨酸残基与其他磷酸化残基。

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