Miyahira Andrea K, Soule Howard R
Department of Science, Prostate Cancer Foundation, Santa Monica, California.
Prostate. 2019 Sep;79(12):1471-1486. doi: 10.1002/pros.23872. Epub 2019 Jul 23.
The 25th Annual Prostate Cancer Foundation (PCF) Scientific Retreat was held in Carlsbad, CA, from 26 to 28 October 2018.
The PCF Scientific Retreat is the foremost scientific research conference in the world that focuses on the most significant and promising recent advancements in basic, translational, and clinical prostate cancer research, as well as research from other fields that has substantial potential to advance prostate cancer research.
The major topic areas discussed at this year's meeting included (a) new insights into prostate cancer biology and treatment; (b) approaches for accelerating precision medicine for prostate cancer; (c) prostate-specific membrane antigen-targeted therapy and imaging for prostate cancer; (d) updates on Poly (ADP-ribose) polymerase (PARP)-inhibitor clinical trial results; (e) the biology and role of prostate cancer stem cells; (f) new approaches for targeting the androgen receptor and other steroid hormone receptor pathways; (g) racial disparities in prostate cancer treatment and outcomes; (h) the role of the nervous system in prostate cancer development and progression; (i) the role of the WNT signaling pathway in normal prostate and prostate cancer biology; (j) novel immunotherapy approaches; and (k) the ecology of prostate cancer.
This article reviews the research presented by the speakers at the 2018 PCF Scientific Retreat for the purpose of disseminating this knowledge to the global research community and ultimately accelerating new understandings and treatment strategies for prostate cancer.
第25届前列腺癌基金会（PCF）科学研讨会于2018年10月26日至28日在加利福尼亚州卡尔斯巴德举行。
PCF科学研讨会是世界上最重要的科学研究会议，专注于基础、转化和临床前列腺癌研究中最新的重大且有前景的进展，以及其他领域中对推进前列腺癌研究有巨大潜力的研究。
今年会议讨论的主要主题领域包括：（a）前列腺癌生物学和治疗的新见解；（b）加速前列腺癌精准医学的方法；（c）前列腺特异性膜抗原靶向治疗及前列腺癌成像；（d）聚（ADP-核糖）聚合酶（PARP）抑制剂临床试验结果的更新；（e）前列腺癌干细胞的生物学特性和作用；（f）靶向雄激素受体和其他类固醇激素受体途径的新方法；（g）前列腺癌治疗和结局中的种族差异；（h）神经系统在前列腺癌发生和发展中的作用；（i）WNT信号通路在正常前列腺和前列腺癌生物学中的作用；（j）新型免疫治疗方法；以及（k）前列腺癌的生态学。
本文回顾了2018年PCF科学研讨会上演讲者所展示的研究，目的是将这些知识传播给全球研究界，并最终加速对前列腺癌的新认识和治疗策略。
