Department of Chemistry , University of Cambridge , Lensfield Road , Cambridge CB2 1EW , United Kingdom.
Medicine Design , Pfizer, Inc. , Eastern Point Road , Groton , Connecticut 06340 , United States.
Org Lett. 2019 Aug 2;21(15):6140-6144. doi: 10.1021/acs.orglett.9b02307. Epub 2019 Jul 23.
Mild cross-coupling reaction between benzylboronic esters with carbonyl compounds and some imines was achieved under visible-light-induced iridium-catalyzed photoredox conditions. Functional group tolerance was demonstrated by 51 examples, including 13 heterocyclic compounds. Gram-scale reaction was realized through the use of computer-controlled continuous flow photoreactors.
在可见光诱导的铱光氧化还原条件下，实现了芳基硼酸酯与羰基化合物和一些亚胺的温和交叉偶联反应。通过 51 个实例，包括 13 个杂环化合物，证明了官能团的耐受性。通过使用计算机控制的连续流动光反应器实现了克级规模的反应。
