Department of Neurology, Yijishan Hospital, Wannan Medical College, Wuhu, Anhui Province, P.R. China.
DNA Cell Biol. 2019 Aug;38(8):808-813. doi: 10.1089/dna.2018.4565. Epub 2019 Jul 23.
This study aims to investigate whether a relationship exists between the polymorphism of gene and poststroke depression (PSD). A total of 82 PSD patients and 115 nondepression patient (NPSD) controls were included in this study. All patients were evaluated using the Hamilton Rating Scale for Depression to determine the severity of depression and complete the packet. PSD patients were diagnosed in accordance with the DSM-V criteria. The polymorphism of was genotyped through fluorescence hybridization and chromosome karyotype analysis system. The PSD ( = 82) and NPSD groups ( = 115) had a total prevalence rate of 41.6%. The prevalence of PSD in men was 58.5%, whereas that in women was 41.5%, and no statistically significant difference existed between the two groups ( = 1.009; = 0.315). The CC, CT, and TT frequencies of the PSD group were 26.8%, 47.6%, and 25.6%, respectively, whereas those of the NPSD group were 42.6%, 45.2%, and 12.2%, respectively. Based on the CC genotype, the relative risk of homozygous mutant TT was 3.341 ( = 7.869; = 0.005; OR = 3.341), and the T allele frequency in the PSD group was 49.4% higher than that in the NPSD group. The locus gene frequency was 34.8%, and the relative risk of allele T relative to allele C was 1.830 ( = 8.381; = 0.004; OR = 1.830). A certain correlation exists between the C3435T gene polymorphism and PSD in the Han population in South Anhui Province, China, and further studies are needed to confirm our findings.
本研究旨在探讨基因多态性与卒中后抑郁（PSD）之间是否存在关系。共纳入 82 例 PSD 患者和 115 例非抑郁患者（NPSD）作为对照组。所有患者均采用汉密尔顿抑郁量表（HAMD）进行抑郁严重程度评估，并完成问卷调查。PSD 患者的诊断符合 DSM-V 标准。采用荧光杂交及染色体核型分析系统检测基因多态性。PSD 组（ = 82）和 NPSD 组（ = 115）的总患病率为 41.6%。男性 PSD 的患病率为 58.5%，女性为 41.5%，两组间无统计学差异（ = 1.009； = 0.315）。PSD 组的 CC、CT 和 TT 频率分别为 26.8%、47.6%和 25.6%，NPSD 组分别为 42.6%、45.2%和 12.2%。基于 CC 基因型，纯合突变 TT 的相对风险为 3.341（ = 7.869； = 0.005；OR = 3.341），PSD 组 T 等位基因频率比 NPSD 组高 49.4%。该基因座的等位基因频率为 34.8%，T 等位基因相对于 C 等位基因的相对风险为 1.830（ = 8.381； = 0.004；OR = 1.830）。在中国皖南地区汉族人群中，C3435T 基因多态性与 PSD 存在一定相关性，需要进一步研究来证实我们的发现。
