Department of Neurology, Yijishan Hospital, The First Affiliated Hospital of Wannan Medical College, Wuhu 241000, China.
Department of Cardiology, The No. 2 People's Hospital of Hefei, Hefei 230000, China.
Oxid Med Cell Longev. 2020 Feb 15;2020:3084120. doi: 10.1155/2020/3084120. eCollection 2020.
Elderly population is in high risk of carotid atherosclerosis and artery stenosis (CAS). It has been proved that PON1 polymorphism is associated with low-density lipoprotein (LDL) oxidation, which plays an important role in artery atherosclerosis. CAS is an important cause of ischemic stroke. This study is aimed at investigating the association of PON1 (rs662) polymorphism with the risk of CAS among elderly Chinese population. Consecutive elderly patients with CAS were enrolled into the study. Genotyping for PON1 (rs662) polymorphism was performed on all participants. There were 310 CAS patients in this study, with 88 symptomatic CAS and 222 asymptomatic CAS. G allele had a frequency of 59.66% in symptomatic CAS (sCAS); and A allele had an incidence of 36.93% in asymptomatic CAS (aCAS) ( < 0.05). In all CAS patients with and without symptom, no associations were found in any genotype comparison. However, among aCAS subjects, based on GA phenotype, the odds ratio (OR) of the mutant GG with stenosis severity was 0.20 ( = 0.01). The OR of GG+GA mutation was 0.28 for moderate/severe severity, compared with GA type ( = 0.03). This study indicates that PON1 (rs662) polymorphism is not associated with the presence of symptom among CAS patients. Moreover, PON1 (rs662) polymorphism correlates with stenosis severity among aCAS.
老年人群易患颈动脉粥样硬化和动脉狭窄（CAS）。已有研究证明，PON1 多态性与低密度脂蛋白（LDL）氧化有关，而 LDL 氧化在动脉粥样硬化中起重要作用。CAS 是缺血性脑卒中的重要病因。本研究旨在探讨 PON1（rs662）多态性与中国老年人群 CAS 风险的相关性。连续纳入了患有 CAS 的老年患者。对所有参与者进行 PON1（rs662）多态性的基因分型。本研究共纳入 310 例 CAS 患者，其中 88 例为有症状 CAS（sCAS），222 例为无症状 CAS（aCAS）。G 等位基因在有症状 CAS（sCAS）中的频率为 59.66%；在无症状 CAS（aCAS）中，A 等位基因的发生率为 36.93%（<0.05）。在所有有症状和无症状的 CAS 患者中，任何基因型的比较均未发现相关性。然而，在 aCAS 患者中，根据 GA 表型，突变 GG 型狭窄严重程度的比值比（OR）为 0.20（=0.01）。与 GA 型相比，GG+GA 突变的 OR 为 0.28，用于中度/重度狭窄（=0.03）。本研究表明，PON1（rs662）多态性与 CAS 患者的症状出现无关。此外，PON1（rs662）多态性与 aCAS 的狭窄严重程度相关。
