Université Paris Descartes, Sorbonne Paris Cité, Faculté de Médecine, Assistance Publique - Hôpitaux de Paris (AP-HP), Service de Chirurgie Gynécologie Obstétrique II et Médecine de la Reproduction, Hôpital Universitaire Paris Centre (HUPC), Centre Hospitalier Universitaire (CHU) Cochin, Paris, France.
Equipe Génomique, Epigénétique et Physiopathologie de la Reproduction, Département Développement, Reproduction, Cancer, Inserm U1016, Université Paris Descartes, Sorbonne Paris Cité, Faculté de Médecine, AP-HP, HUPC, CHU Cochin, Paris, France.
PLoS One. 2019 Jul 23;14(7):e0219497. doi: 10.1371/journal.pone.0219497. eCollection 2019.
To evaluate the association between the endometriosis phenotype and the age at menarche.
An observational, cross-sectional study using prospectively collected data (Canadian Task Force classification II-2).
Single university tertiary referral center.
To be eligible, women had to have undergone their 1st complete surgical exeresis of endometriotic lesions. For each patient, a standardized questionnaire was completed the month before the surgery. Endometriotic lesions were classified into 3 phenotypes: superficial peritoneal endometriosis (SUP), endometrioma (OMA), or deep infiltrating endometriosis (DIE). Patients were divided into 3 groups: early menarche (< 12 years), typical menarche (≥ 12 and ≤ 13 years) and late menarche (> 13 years). The groups were compared in terms of general characteristics, medical history, disease phenotype, and disease severity.
Surgical management for a benign gynecologic condition.
MAIN OUTCOME MEASURE(S): Correlation between the endometriosis phenotype and the age at menarche.
From January 2004 to December 2016, 789 women with histologically confirmed endometriosis were enrolled in the study. The mean age at menarche was 12.9 ± 1.6 years of age, (range 9 to 18). The mean age at menarche and the mean time interval between menarche and the 1st surgery for endometriosis were not significantly different between the three phenotypes (SUP, OMA, DIE). When women with early menarche, typical menarche, or late menarche were compared, no differences were observed in terms of the endometriosis phenotype and the anatomical distribution of the endometriotic lesions.
For women operated for the first time for endometriosis, age at menarche is not associated with the disease phenotype.
评估子宫内膜异位症表型与初潮年龄的关系。
使用前瞻性收集的数据进行的观察性、横断面研究（加拿大任务组分类 II-2）。
单一大学三级转诊中心。
要符合条件，女性必须接受过第 1 次完整的子宫内膜异位症病变手术切除术。对于每位患者，在手术前一个月完成标准化问卷。子宫内膜异位症病变分为 3 种表型：浅表腹膜子宫内膜异位症（SUP）、卵巢子宫内膜异位症（OMA）或深部浸润性子宫内膜异位症（DIE）。患者分为 3 组：初潮早（<12 岁）、初潮晚（≥12 岁且≤13 岁）和晚初潮（>13 岁）。比较各组的一般特征、病史、疾病表型和疾病严重程度。
良性妇科疾病的手术治疗。
子宫内膜异位症表型与初潮年龄的关系。
从 2004 年 1 月至 2016 年 12 月，共纳入 789 例组织学证实的子宫内膜异位症患者。初潮年龄的平均值为 12.9±1.6 岁（范围 9 至 18 岁）。三种表型（SUP、OMA 和 DIE）之间，初潮年龄和初潮至子宫内膜异位症第 1 次手术的时间间隔平均值没有显著差异。比较初潮早、初潮晚和晚初潮的女性，子宫内膜异位症表型和子宫内膜异位症病变的解剖分布无差异。
对于首次因子宫内膜异位症而接受手术的女性，初潮年龄与疾病表型无关。
