Borghese Bruno, Chartier Mélanie, Souza Carlos, Santulli Pietro, Lafay-Pillet Marie-Christine, de Ziegler Dominique, Chapron Charles
Université Paris Descartes, Sorbonne Paris Cité, Service de Gynécologie-Obstétrique 2 et Médecine de la Reproduction, Groupe Hospitalier Cochin, AP-HP, 75014 Paris, France ; Institut Cochin, Université Paris Descartes, Sorbonne Paris Cité, CNRS (UMR 8104), 75014 Paris, France ; Inserm, U1016, 75014 Paris, France.
Université Paris Descartes, Sorbonne Paris Cité, Service de Gynécologie-Obstétrique 2 et Médecine de la Reproduction, Groupe Hospitalier Cochin, AP-HP, 75014 Paris, France.
Biomed Res Int. 2014;2014:618964. doi: 10.1155/2014/618964. Epub 2014 Aug 27.
The identification of epidemiological factors increasing the risk of endometriosis could shorten the time to diagnosis. Specific blood groups may be more common in patients with endometriosis.
We designed a cross-sectional study of 633 Caucasian women living in the same geographic area. Study group included 311 patients with histologically proven endometriosis. Control group included 322 patients without endometriosis as checked during surgery. Frequencies of ABO and Rhesus groups in the study and control groups were compared using univariate and multivariate analyses.
We observed a higher proportion of Rh-negative women in the study group, as compared to healthy controls. Multivariate analysis showed that Rh-negative women are twice as likely to develop endometriosis (aOR = 1.90; 95% CI: 1.20-2.90). There was no significant difference in ABO group distribution between patients and controls. There was no difference when taking into account either the clinical forms (superficial endometriosis, endometrioma, and deep infiltration endometriosis) or the rAFS stages.
Rh-negative women are twice as likely to develop endometriosis. Chromosome 1p, which contains the genes coding for the Rhesus, could also harbor endometriosis susceptibility genes.
确定增加子宫内膜异位症风险的流行病学因素可缩短诊断时间。特定血型在子宫内膜异位症患者中可能更为常见。
我们对居住在同一地理区域的633名白种女性进行了一项横断面研究。研究组包括311例经组织学证实患有子宫内膜异位症的患者。对照组包括322例在手术中检查未患子宫内膜异位症的患者。使用单变量和多变量分析比较研究组和对照组中ABO血型和恒河猴血型的频率。
与健康对照组相比，我们观察到研究组中Rh阴性女性的比例更高。多变量分析表明，Rh阴性女性患子宫内膜异位症的可能性是正常人的两倍（调整后比值比 = 1.90；95%可信区间：1.20 - 2.90）。患者与对照组之间的ABO血型分布无显著差异。考虑临床类型（浅表性子宫内膜异位症、子宫内膜瘤和深部浸润性子宫内膜异位症）或rAFS分期时也无差异。
Rh阴性女性患子宫内膜异位症的可能性是正常人的两倍。包含编码恒河猴血型基因的1号染色体也可能含有子宫内膜异位症易感基因。
