代谢健康状况和体重指数与抑郁症的关系：观察性研究的系统评价
Metabolically healthy status and BMI in relation to depression: A systematic review of observational studies.
作者信息
Malmir Hanieh, Mirzababaei Atieh, Moradi Sajjad, Rezaei Shahabeddin, Mirzaei Khadijeh, Dadfarma Alireza
机构信息
Department of Community Nutrition, School of Nutritional Sciences and Dietetics, Tehran University of Medical Sciences (TUMS), Tehran, Iran.
Department of Community Nutrition, School of Nutritional Sciences and Dietetics, Tehran University of Medical Sciences (TUMS), Tehran, Iran; Student`s Scientific Research Center, School of Nutritional Sciences and Dietetics, Tehran University of Medical Sciences (TUMS), Tehran, Iran.
出版信息
Diabetes Metab Syndr. 2019 Mar-Apr;13(2):1099-1103. doi: 10.1016/j.dsx.2019.01.027. Epub 2019 Jan 22.
AIM
Findings of association between metabolically healthy status and BMI and risk of depression are controversial. This study aimed to assess the relation between metabolically healthy status and BMI and depression.
METHODS
All published studies up to 25 June 2018 were searched by using the databases of PubMed, ISI Web of Science, SCOPUS and Google Scholar and following key words were used: metabolically AND (healthy OR unhealthy OR benign) AND (overweight OR obes* OR "over weight") AND phenotype AND (depression OR depress* OR "depressive disorder").
RESULTS
After screening title and abstract and considering inclusion criteria, 5 studies were found to be included in our study. Metabolically unhealthy obesity was associated with 30%-83% increased risk of depression and metabolically unhealthy non-obesity was associated with 19%-60% increased risk of depression. Metabolically healthy obesity was not associated with the risk of depression in all studies.
CONCLUSIONS
In conclusion, metabolically health status and BMI are associated with risk of depression. Metabolically unhealthy situation increased risk of depression greater than metabolically healthy status.
目的
代谢健康状态与体重指数（BMI）以及抑郁症风险之间的关联研究结果存在争议。本研究旨在评估代谢健康状态与BMI和抑郁症之间的关系。
方法
通过使用PubMed、ISI科学网、Scopus和谷歌学术数据库检索截至2018年6月25日的所有已发表研究，并使用以下关键词：代谢且（健康或不健康或良性）且（超重或肥胖或“超重”）且表型且（抑郁症或抑郁或“抑郁障碍”）。
结果
在筛选标题和摘要并考虑纳入标准后，发现有5项研究纳入我们的研究。代谢不健康肥胖与抑郁症风险增加30%-83%相关，代谢不健康非肥胖与抑郁症风险增加19%-60%相关。在所有研究中，代谢健康肥胖与抑郁症风险无关。
结论
总之，代谢健康状态和BMI与抑郁症风险相关。代谢不健康状况比代谢健康状态更易增加抑郁症风险。
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