Obesity Research Center, Research Institute for Endocrine Sciences, Shahid Beheshti University of Medical Sciences, Tehran, Iran.
Obesity Research Center, Research Institute for Endocrine Sciences, Shahid Beheshti University of Medical Sciences, Tehran, Iran.
Nutr Metab Cardiovasc Dis. 2022 Sep;32(9):2041-2051. doi: 10.1016/j.numecd.2022.06.010. Epub 2022 Jun 16.
Discrepant results have been demonstrated regarding the cardiovascular (CV) risk of populations with metabolically healthy overweight/obesity (MHO) who were transitioned into metabolically unhealthy states. So, the objective of this systematic review and meta-analysis was to estimate the risk of cardiovascular diseases (CVD) incidence in individuals with transitional MHO phenotype.
A literature review was done in PubMed, Scopus, EMBASE, and google scholar databases. Pooled HRs for all fatal and nonfatal CV events were computed using random-effect models for transitional MHOs in general as well as for each sex subgroup separately. This systematic review and meta-analysis included a total of 7 prospective observational studies with a total of 7,720,165 participants, published between 2018 and 2020. The mean follow-up duration of participants was 11.7 (5.5) years. Overall, the transitional MHO individuals had a significant risk of CVD incidence [HR = 1.42, 95% CI (1.24-1.60)]. In addition, in both male and female subgroups, unstable MHO phenotype demonstrated a significant CVD risk and HRs for incident CVD in males and females were 1.51 (1.07-1.96) and 1.71 (1.08-2.34), respectively.
Transition from MHO to unhealthy state throughout follow-up elevated the risk of CVD in both male and female groups. This can explain the association between MHO and incidence of CV events especially with longer follow up period.
CRD42021270225.
代谢健康型超重/肥胖（MHO）人群转变为代谢不健康状态后，其心血管（CV）风险存在差异。因此，本系统评价和荟萃分析的目的是评估具有过渡性 MHO 表型的个体发生心血管疾病（CVD）的风险。
在 PubMed、Scopus、EMBASE 和谷歌学术数据库中进行了文献综述。使用随机效应模型计算了所有致命和非致命 CV 事件的汇总 HR，分别针对一般过渡性 MHO 以及每个性别亚组进行了计算。本系统评价和荟萃分析共纳入了 7 项前瞻性观察性研究，共有 7720165 名参与者，发表时间为 2018 年至 2020 年。参与者的平均随访时间为 11.7（5.5）年。总体而言，过渡性 MHO 个体发生 CVD 的风险显著增加[HR=1.42，95%CI（1.24-1.60）]。此外，在男性和女性亚组中，不稳定的 MHO 表型也显示出显著的 CVD 风险，男性和女性发生 CVD 的 HR 分别为 1.51（1.07-1.96）和 1.71（1.08-2.34）。
在随访过程中，从 MHO 向不健康状态的转变增加了男性和女性两组发生 CVD 的风险。这可以解释 MHO 与 CV 事件发生率之间的关联，特别是在随访时间较长的情况下。
登记号 PROSPERO：CRD42021270225。
