乙基汞硫柳汞对人中性粒细胞花生四烯酸代谢的多种影响。
Multiple effects of ethylmercurithiosalicylate on the metabolization of arachidonic acid by human neutrophils.
作者信息
Stüning M, Brom J, König W
机构信息
Lehrstuhl für Medizinische Mikrobiologie und Immunologie, Arbeitsgruppe Infektabwehrmechanismen, Ruhr-Universität, Bochum, FRG.
出版信息
Prostaglandins Leukot Essent Fatty Acids. 1988 Apr;32(1):1-7. doi: 10.1016/0952-3278(88)90086-5.
The effects of ethylmercurithiosalicylate (thimerosal) on the transformation of arachidonic acid via the 5-lipoxygenase pathway in human leukocytes stimulated with the Ca-ionophore A23187 were studied. Thimerosal inhibited acyltransferase, 5-lipoxygenase and the omega-oxidation system of LTB4 in a concentration-dependent fashion which was characteristic for the individual metabolites. LTA4 hydrolase activity was not affected. The inhibitory effects of thimerosal occurred instantaneously. The effects of the drug were not influenced by the concentration of the stimulus Ca-ionophore A23187.
研究了硫柳汞（乙基汞硫代水杨酸盐）对钙离子载体A23187刺激的人白细胞中花生四烯酸经5-脂氧合酶途径转化的影响。硫柳汞以浓度依赖性方式抑制酰基转移酶、5-脂氧合酶和白三烯B4的ω-氧化系统，这是各代谢产物的特征。白三烯A4水解酶活性不受影响。硫柳汞的抑制作用即刻出现。该药物的作用不受刺激物钙离子载体A23187浓度的影响。
Zotero 插件