Department of Biochemistry, University of Nebraska, Lincoln, NE 68588, USA.
Biomolecules. 2019 Jul 11;9(7):273. doi: 10.3390/biom9070273.
The Stabilin receptors are a two-member family in the type H class of scavenger receptors. These dynamic receptors bind and internalize multiple ligands from the cell surface for the purpose of clearing extracellular material including some synthetic drugs and for sensing the external environment of the cell. Stabilin-1 was the first receptor to be cloned, though the biological activity of Hyaluronic Acid Receptor for Endocytosis (HARE)/Stabilin-2 was observed about 10 years prior to the cloning of Stabilin-1. Stabilin-1 has a more diverse expression profile among the tissues than HARE/Stabilin-2. This review will focus on HARE/Stabilin-2 and its interactions with hyaluronan, heparin, and phosphorothioate antisense oligonucleotides and what is known about how this receptor participates in signaling upon ligand binding.
稳定素受体是 I 型清道夫受体中两个成员组成的家族。这些动态受体结合并内化细胞表面的多种配体，目的是清除细胞外物质，包括一些合成药物，并感知细胞的外部环境。稳定素-1是第一个被克隆的受体，尽管透明质酸受体内吞作用（HARE）/稳定素-2的生物学活性在克隆稳定素-1之前约 10 年就被观察到。稳定素-1在组织中的表达谱比 HARE/稳定素-2更广泛。这篇综述将集中讨论 HARE/稳定素-2及其与透明质酸、肝素和硫代磷酸酯反义寡核苷酸的相互作用，以及已知该受体在配体结合时如何参与信号转导。
