Department of Physiology, Showa University School of Medicine, 1-5-8 Hatanodai, Shinagawa, Tokyo 142-8555, Japan.
Thermal Biology group, Exploratory Research Center on Life and Living Systems, National Institutes for Natural Sciences, 5-1 Aza-higashiyama, Myodaiji, Okazaki, Aichi 444-8787, Japan.
Int J Mol Sci. 2019 Jul 11;20(14):3411. doi: 10.3390/ijms20143411.
Receptor-type ion channels are critical for detection of noxious stimuli in primary sensory neurons. Transient receptor potential (TRP) channels mediate pain sensations and promote a variety of neuronal signals that elicit secondary neural functions (such as calcitonin gene-related peptide [CGRP] secretion), which are important for physiological functions throughout the body. In this review, we focus on the involvement of TRP channels in sensing acute pain, inflammatory pain, headache, migraine, pain due to fungal infections, and osteo-inflammation. Furthermore, action potentials mediated via interactions between TRP channels and the chloride channel, anoctamin 1 (ANO1), can also generate strong pain sensations in primary sensory neurons. Thus, we also discuss mechanisms that enhance neuronal excitation and are dependent on ANO1, and consider modulation of pain sensation from the perspective of both cation and anion dynamics.
受体型离子通道对于初级感觉神经元中有害刺激的检测至关重要。瞬时受体电位 (TRP) 通道介导疼痛感觉，并促进引发次级神经功能的各种神经元信号（如降钙素基因相关肽 [CGRP] 分泌），这些信号对于全身的生理功能很重要。在这篇综述中，我们重点关注 TRP 通道在感知急性疼痛、炎症性疼痛、头痛、偏头痛、真菌感染引起的疼痛和骨炎症中的作用。此外，通过 TRP 通道与氯离子通道 anoctamin 1（ANO1）相互作用介导的动作电位也可以在初级感觉神经元中产生强烈的疼痛感觉。因此，我们还讨论了增强神经元兴奋的机制，这些机制依赖于 ANO1，并从阳离子和阴离子动力学的角度考虑疼痛感觉的调节。
