Department of Molecular Microbiology and Immunology, Johns Hopkins Bloomberg School of Public Health, Baltimore, Maryland, USA
Division of Internal Medicine, The University of Texas MD Anderson Cancer Center, Houston, Texas, USA.
mBio. 2019 Jul 23;10(4):e01397-19. doi: 10.1128/mBio.01397-19.
The most enigmatic aspect of the rise of as a human pathogen is that it emerged simultaneously on three continents, with each clade being genetically distinct. Although new pathogenic fungal species are described regularly, these are mostly species associated with single cases in individuals who are immunosuppressed. In this study, we used phylogenetic analysis to compare the temperature susceptibility of with those of its close relatives and to use these results to argue that it may be the first example of a new fungal disease emerging from climate change, with the caveat that many other factors may have contributed.
棘白菌素类耐药的最神秘方面是它作为一种人类病原体同时出现在三大洲,每个分支在遗传上都是不同的。虽然经常有新的致病性真菌物种被描述,但这些大多是与免疫抑制个体中的单个病例相关的物种。在这项研究中,我们使用系统发育分析比较了棘白菌素类耐药与近亲的温度敏感性,并利用这些结果来证明它可能是气候变化引发的新真菌病的第一个例子,但需要注意的是,可能还有许多其他因素也起到了作用。