Elhaj Ahmad, Jawhar Duaa, Elfaki Nawal
Department of Neurosurgery, Saqr Hospital, Emirates Health Service, Ras Al-Khaimah, United Arab Emirates.
Department of Pharmacy (Clinical Pharmacy), Saqr Hospital, Emirates Health Service, Ras Al Khaimah, United Arab Emirates.
J Med Case Rep. 2025 Aug 5;19(1):393. doi: 10.1186/s13256-025-05088-3.
Candida auris ventriculitis is a rare but serious condition associated with high mortality rates. The available literature on its management is limited, and there are few documented successful treatment strategies or care plans.
We report the case of a 34-year-old male patient from South Asia with Candida auris infection of an external ventricular shunt. The patient was initially treated with a combination of injectable amphotericin B liposomal and caspofungin for 21 days. This was followed by a 15-day course of injectable amphotericin liposomal and voriconazole. Subsequently, voriconazole monotherapy was administered orally for an additional 11 days. Notably, all antifungals used were determined to be sensitive on the basis of cerebrospinal fluid culture and sensitivity results. Source control was achieved after 20 days of initiating therapy, leading to the permanent removal of the shunt.
Candida auris ventriculitis can be effectively managed with systemic antifungal therapy and appropriate source control measures.
耳念珠菌脑室炎是一种罕见但严重的疾病，死亡率很高。关于其治疗的现有文献有限，记录在案的成功治疗策略或护理计划很少。
我们报告了一例来自南亚的34岁男性患者，其体外脑室分流管发生耳念珠菌感染。患者最初接受注射用两性霉素B脂质体和卡泊芬净联合治疗21天。随后进行了为期15天的注射用两性霉素脂质体和伏立康唑治疗。随后口服伏立康唑单药治疗11天。值得注意的是，根据脑脊液培养和药敏结果，所有使用的抗真菌药物均被确定为敏感。开始治疗20天后实现了源头控制，导致分流管被永久移除。
耳念珠菌脑室炎可通过全身抗真菌治疗和适当的源头控制措施有效管理。
