INSERM U1105, Université de Picardie, CURS, Amiens, France.
Faculty of Electrical and Computer Engineering, K.N. Toosi University of Technology, Tehran, Iran.
Sci Rep. 2019 Jul 23;9(1):10654. doi: 10.1038/s41598-019-47064-0.
Sensory development of the human brain begins prenatally, allowing cortical auditory responses to be recorded at an early age in preterm infants. Despite several studies focusing on the temporal characteristics of preterm infants' cortical responses, few have been conducted on frequency analysis of these responses. In this study, we performed frequency and coherence analysis of preterm infants' auditory responses to series of syllables and also investigated the functional brain asymmetry of preterm infants for the detection of the regularity of auditory stimuli. Cortical auditory evoked potentials (CAEPs) were recorded in 16 preterm infants with a mean recording age of 31.48 weeks gestational age (29.57-34.14 wGA) in response to a repetitive syllabic stimulus. Peak amplitudes of the frequency response at the target frequency and the first harmonic, as well as the phase coherence (PC) at the target frequency were extracted as age-dependent variables. A functional asymmetry coefficient was defined as a lateralization index for the amplitude of the target frequency at each electrode site. While the findings revealed a significant positive correlation between the mean amplitude at the target frequency vs. age (R2 = 0.263, p = 0.042), no significant correlation was observed for age-related changes of the mean amplitude at the first harmonic. A significant correlation was also observed between the mean PC and age (R2 = 0.318, p = 0.023). A right hemisphere lateralization over many channels was also generally observed. The results demonstrate that rightward lateralization for slow rate modulation, previously observed in adults, children and newborns, appears to be in place at a very young age, even in preterm infants.
人类大脑的感觉发育始于产前，这使得皮质听觉反应能够在早产儿的早期被记录下来。尽管有几项研究集中在早产儿皮质反应的时间特征上，但很少有研究对这些反应的频率分析进行研究。在这项研究中，我们对早产儿听觉反应的频率和相干性进行了分析，并研究了早产儿的功能性大脑不对称，以检测听觉刺激的规律性。对 16 名平均胎龄 31.48 周（29.57-34.14 wGA）的早产儿进行了皮质听觉诱发电位（CAEP）记录，以响应重复的音节刺激。提取目标频率和第一谐频的频率响应的峰值幅度以及目标频率的相位相干性（PC）作为与年龄相关的变量。功能不对称系数被定义为每个电极部位目标频率振幅的侧化指数。虽然研究结果显示目标频率的平均振幅与年龄之间存在显著的正相关关系（R2=0.263，p=0.042），但第一谐频的平均振幅与年龄的相关性变化没有显著相关性。平均 PC 与年龄之间也存在显著相关性（R2=0.318，p=0.023）。还观察到许多通道上的平均 PC 与年龄之间存在显著相关性（R2=0.318，p=0.023）。还观察到许多通道上的平均 PC 与年龄之间存在显著相关性（R2=0.318，p=0.023）。还观察到许多通道上的平均 PC 与年龄之间存在显著相关性（R2=0.318，p=0.023）。还观察到许多通道上的平均 PC 与年龄之间存在显著相关性（R2=0.318，p=0.023）。右半球偏侧化也普遍存在。研究结果表明，成年人、儿童和新生儿以前观察到的慢率调制的右半球偏侧化似乎在很小的时候就已经存在，即使是早产儿。
