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镧系元素放射性药物对的制备及其体内 PET/CT 显像

Production and in vivo PET/CT imaging of the theranostic pair La.

机构信息

Department of Medical Physics, University of Wisconsin-Madison, Madison, WI, 53705, USA.

Department of Radiology, University of Wisconsin-Madison, Madison, WI, 53705, USA.

出版信息

Sci Rep. 2019 Jul 23;9(1):10658. doi: 10.1038/s41598-019-47137-0.

DOI:10.1038/s41598-019-47137-0
PMID:31337833
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC6650468/
Abstract

The present study describes a novel method for the low energy cyclotron production and radiochemical isolation of no-carrier-added La from bulk Ba. This separation strategy combines precipitation and single-column extraction chromatography to afford an overall radiochemical yield (92 ± 2%) and apparent molar activity (22 ± 4 Mbq/nmol) suitable for the radiolabeling of DOTA-conjugated vectors. The produced La has a radiochemical and radionuclidic purity amenable for La/La-based cancer theranostic applications. Longitudinal PET/CT images acquired using the positron-emitting La and ex vivo biodistribution data separately corroborated the accumulation of unchelated La ions in bone and the liver.

摘要

本研究描述了一种从大量钡中低能回旋加速器生产无载体添加镧并进行放射化学分离的新方法。这种分离策略结合沉淀和单柱萃取色谱法，可获得适合 DOTA 缀合载体标记的总放射化学产率（92±2%）和表观比活度（22±4 Mbq/nmol）。所生产的镧具有适合镧/镧为基础的癌症治疗应用的放射化学和放射性核纯度。使用发射正电子的镧和离体生物分布数据分别获得的纵向 PET/CT 图像证实了未配位的镧离子在骨骼和肝脏中的积累。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/37ed/6650468/b73df093f052/41598_2019_47137_Fig5_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/37ed/6650468/0ebf4e86bfee/41598_2019_47137_Fig1_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/37ed/6650468/189d5fa37b9d/41598_2019_47137_Fig2_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/37ed/6650468/3a9b02294198/41598_2019_47137_Fig3_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/37ed/6650468/4e7ac65378c7/41598_2019_47137_Fig4_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/37ed/6650468/b73df093f052/41598_2019_47137_Fig5_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/37ed/6650468/0ebf4e86bfee/41598_2019_47137_Fig1_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/37ed/6650468/189d5fa37b9d/41598_2019_47137_Fig2_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/37ed/6650468/3a9b02294198/41598_2019_47137_Fig3_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/37ed/6650468/4e7ac65378c7/41598_2019_47137_Fig4_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/37ed/6650468/b73df093f052/41598_2019_47137_Fig5_HTML.jpg

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