4-羟基-2,3-反式壬烯醛对血小板功能的影响。

Effect of 4-hydroxy-2,3-trans-nonenal on platelet function.

作者信息

Selley M L, McGuiness J A, Jenkin L A, Bartlett M R, Ardlie N G

机构信息

Department of Medicine and Clinical Science, John Curtin School of Medical Research, Australian National University, Canberra, ACT.

出版信息

Thromb Haemost. 1988 Apr 8;59(2):143-6.

PMID:3133806

Abstract

4-Hydroxy-2,3-trans-nonenal (HNE), an aldehyde end-product of lipid peroxidation, potentiated aggregation and increased thromboxane A2 formation in platelets challenged with ADP, thrombin or the ionophore A23187. These effects were observed at HNE concentrations in the range 10-100 microM. Platelet responses to collagen, epinephrine and arachidonic acid were not affected by HNE. Concentrations of HNE in excess of 100 microM inhibited platelet activation. HNE increased the release of 3H-arachidonic acid from prelabelled platelet phospholipids in response to thrombin or ADP. It is proposed that HNE may play an important role in controlling platelet function by regulating the activity of phospholipase A2.

摘要

4-羟基-2,3-反式壬烯醛（HNE）是脂质过氧化的醛类终产物，在受到二磷酸腺苷（ADP）、凝血酶或离子载体A23187刺激的血小板中，它会增强聚集并增加血栓素A2的形成。在10-100微摩尔范围内的HNE浓度下观察到了这些效应。血小板对胶原蛋白、肾上腺素和花生四烯酸的反应不受HNE影响。超过100微摩尔的HNE浓度会抑制血小板活化。HNE会增加预先标记的血小板磷脂中3H-花生四烯酸因凝血酶或ADP刺激而释放。有人提出，HNE可能通过调节磷脂酶A2的活性在控制血小板功能中发挥重要作用。